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Torkamani A, Kannan N, Taylor SS , Schork NJ.
Congenital disease SNPs target lineage specific structural elements in protein kinases.
Proc Natl Acad Sci U S A. 105(26):9011-6 (2008).
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Kannan N, Taylor SS .
Rethinking pseudokinases.
Cell. 133(2):204-5 (2008).
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Kornev AP, Taylor SS, Ten Eyck LF.
A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains.
PLoS Comput Biol. 4(4):e1000056 (2008).
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Ma Y, Taylor SS.
A molecular switch for targeting between ER and mitochondria:Conversion of a mitochondria targeting element into an ER targeting signal in dAKAP1.
J Biol Chem. 283(17):11743-51 (2008).
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Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G.
Allosteric cooperativity in protein kinase A.
Proc Natl Acad Sci U S A. 105(2):506-11 (2008).
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Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter CJ, Taylor SS.
Evolution of allostery in the cyclic nucleotide binding module.
Genome Biol. 8(12):R264 (2007).
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Ten Eyck LF, Taylor SS, Kornev AP.
Conserved spatial patterns across the protein kinase family.
Biochim Biophys Acta. 1784(1):238-243 (2007).
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Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N.
Signaling through cAMP and cAMP-dependent protein kinase: Diverse strategies for drug design.
Biochim Biophys Acta. 1784(1):16-26 (2007).
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Valiev M, Yang J, Adams JA,Taylor SS, Weare JH.
Phosphorylation Reaction in cAPK Protein Kinase-Free Energy Quantum Mechanical/Molecular Mechanics Simulations.
J Phys Chem B. 111(47):13455-64. (2007).
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Kannan N, Neuwald AF,Taylor SS.
Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases.
Biochim Biophys Acta. 1784(1):27-32 (2007).
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Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA,Taylor SS.
R-subunit Isoform Specificity in Protein Kinase A: Distinct Features of Protein Interfaces in PKA Types I and II by Amide H/(2)H Exchange Mass Spectrometry.
J Mol Biol. 374(2):487-99 (2007).
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Wu J, Brown SH, von Daake S, Taylor SS.
PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.
Science. 318(5848):274-9 (2007).
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Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A,Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE.
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways.
J Cell Biol. 178(7):1265-78 (2007).
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Kim C, Cheng CY, Saldanha SA, Taylor SS.
PKA-I Holoenzyme Structure Reveals a Mechanism for cAMP-Dependent Activation.
Cell. 130(6):1032-43 (2007).
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Martin BR, Deerinck TJ, Ellisman MH, Taylor SS,Tsien RY.
Isoform-Specific PKA Dynamics Revealed by Dye-Triggered Aggregation and DAKAP1alpha-Mediated Localization in Living Cells.
Chem Biol. 14(9):1031-42 (2007).
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Anand G, Taylor SS,Johnson DA.
Cyclic-AMP and Pseudosubstrate Effects on Type-I A-Kinase Regulatory and Catalytic Subunit Binding Kinetics.
Biochemistry. 46(32):9283-91 (2007).
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Humphries KM, Pennypacker JK, Taylor SS.
Redox regulation of PKA signaling: Kinase versus phosphatase inactivation.
J Biol Chem. 282(30):22072-9 (2007).
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Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon JE.
Identification of a molecular target for the Yersinia protein kinase A.
Mol Cell. 26(4):465-77 (2007).
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Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS,Taylor SS,Ginsberg MH.
alpha4 Integrins are Type I cAMP-dependent protein kinase-anchoring proteins.
Nat Cell Biol. 9(4):415-21 (2007). Pubmed
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Kannan N,Taylor SS, Zhai Y, Venter JC, Manning G.
Structural and Functional Diversity of the Microbial Kinome.
PLoS Biol. 5(3):e17 (2007).
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Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor SS, Strausberg RL, Frazier M, Venter JC.
The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families.
PLoS Biol. 5(3):e16 (2007). Pubmed
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Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor SS.
Identification of ChChd3 as a novel substrate of PKA using an analog-sensitive catalytic subunit.
J Biol Chem. 282(20):14952-9 (2007).
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Kannan N, Haste N, Taylor SS, Neuwald AF.
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.
Proc Natl Acad Sci U S A. 104(4):1272-7 (2007).
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Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G.
cAMP activation of PKA defines an ancient signaling mechanism.
Proc Natl Acad Sci U S A. 104(1):93-8 (2006).
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Saldanha SA, Kaler G, Cottam HB, Abagyan R, Taylor SS.
Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A.
Anal Chem. 78(24):8265-72 (2006).
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Kornev AP, Haste NM, Taylor SS, Eyck LF.
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism.
Proc Natl Acad Sci U S A. 103(47):17783-8 (2006).
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Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA, Taylor SS.
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase.
Mol Cell. 24(3):397-408 (2006).
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Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, McCallion AS, Hodgson S, Clarke S, Mondellini P, Leyland J, Pierotti MA, Whittaker J, Taylor SS, Bongarzone I, Ponder BA.
RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B.
Cancer Res. 66(20):10179-87 (2006).
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Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G.
NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit.
J Biomol NMR. 36 Suppl 1:64 (2006).
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Kim C, Vigil D, Anand G, Taylor SS.
Structure and dynamics of PKA signaling proteins.
Eur J Cell Biol. 85(7):651-4 (2006)
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Vigil D, Blumenthal DK, Taylor SS, Trewhella J.
Solution Scattering Reveals Large Differences in the Global Structures of Type II Protein Kinase A Isoforms.
J Mol Biol. 357(3):880-9 (2006).
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Niedner RH, Buzko OV, Haste NM, Taylor A, Gribskov M,Taylor SS.
Protein kinase resource: an integrated environment for phosphorylation research.
Proteins. 63(1):78-86(2006).
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Gullingsrud J, Kim C,Taylor SS, McCammon JA.
Dynamic binding of PKA regulatory subunit RIalpha.
Structure. 14(1):141-9(2006).
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Vigil D, Lin JH, Sotriffer CA, Pennypacker JK, McCammon JA,Taylor SS.
A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP.
Protein Sci. 15(1):113-21(2006).
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Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings PA, Taylor SS, Woods VL Jr.
Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange.
Protein Sci. 14(12):2982-92(2005).
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Wu J, Yang J, Kannan N, Madhusudan, Xuong NH, Ten Eyck LF,Taylor SS.
Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.
Protein Sci. 14(11):2871-9(2005).
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Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS.
Dynamics of signaling by PKA.
Biochim Biophys Acta. 1754(1-2):25-37(2005).
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Taylor SS, Haste NM, Ghosh G.
PKR and eIF2alpha: Integration of Kinase Dimerization, Activation, and Substrate Docking.
Cell. 122(6):823-5 (2005).
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Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY.
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes.
Nature. 437(7058):569-73 (2005).
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Vigil D, Blumenthal DK, Taylor SS, Trewhella J.
The conformationally dynamic C helix of the RIalpha -subunit of protein Kinase A mediates isoform specific domain reorganization upon C subunit binding.
J Biol Chem. 280(42):35521-7 (2005).
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Iyer GH, Garrod S, Woods VL Jr, Taylor SS.
Catalytic independent functions of a protein kinase as revealed by a kinae-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase.
J Mol Biol. 351(5):1110-22 (2005).
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Kim C, Xuong NH, Taylor SS.
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA.
Science. 307(5710):690-6 (2005).
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Yang J, Garrod SM, Deal MS, Anand GS, Woods VL Jr,Taylor SS.
Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop.
J Mol Biol. 346(1):191-201 (2005).
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Sastri M, Barraclough DM, Carmicheal PT, Taylor SS.
A-kinase-interacting protein localizes protein kinase A in the nucleus.
Proc Natl Acad Sci USA. 102(2):349-54 (2005).
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Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor SS.
The cAMP binding domain: an ancient signaling module.
Proc Natl Acad Sci USA. 102(1):45-50 (2005).
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Iyer GH, Moore MJ, Taylor SS.
Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase.
J Biol Chem. 280(10):8800-7 (2005).
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Humphries KM, Deal MS, Taylor SS.
Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification.
J Biol Chem. 280(4):2750-8 (2005).
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Burns-Hamuro LL, Barraclough DM, Taylor SS.
Identification and functional analysis of dual-specific A kinase-anchoring protein-2.
Methods Enzymol. 390:354-74 (2004).
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Nolen B, Taylor SS, Ghosh G.
Regulation of protein kinases; controlling activity through activation segment conformation.
Mol Cell. (Camb). 15(5):661-75(2004).
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Wu J, Brown S, Xuong NH, Taylor SS.
RIa Subunit of PKA: A cAMP-free Structure Reveals a Hydrophobic Capping Mechanism for Docking cAMP into Site B.
Structure. (Camb). 12(6):1057-65 (2004).
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Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J.
Differential Effect of Substrate Binding on TypeI and TypeII PKA Holoenzyme Dissociation.
Biochemistry 43(19):5629-36 (2004).
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Hamuro Y, Anand GS, Kim JS, Juliano C, Stranz DD, Taylor SS, and Woods VL Jr.
Mapping Intersubunit Interactions of the Regulatory Subunit (RIa) in the Type I Holoenzyme of Protein Kinase A by Enhanced Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS).
J. Mol. Biol. 340(5):1185-96 (2004).
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Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella, J.
C subunits Binding to the Protein Kinase RIa Dimer Induces a Large Conformational Change.
J. Biol. Chem. 279:19084-19090 (2004).
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Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J.
Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions.
J. Mol. Biol. 337(5):1183-94 (2004)
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Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor SS.
Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP.
Biochemistry 43(21):6620-9 (2004).
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Taylor SS, Yang J, Wu J, Haste NM, Radzio-Andzelm E, Anand G.
PKA: a portrait of protein kinase dynamics.
Biochim Biophys Acta.1697(1-2):259-69 (2004).
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Yang J, Ten Eyck LF, Xuong NH, Taylor SS.
Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism.
J Mol Biol. 336(2):473-87 (2004).
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Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS.
Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit.
Biochemistry 43(1):85-96 (2004).
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Zawadzki KM, Taylor SS.
cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP.
J Biol Chem. 279(8):7029-36 (2004).
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Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA.
Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking.
Proc Natl Acad Sci U S A. 100(23):13264-9 (2003).
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Gisler SM, Madjdpour C, Bacic D, Pribanic S, Taylor SS, Biber J, Murer H.
PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells.
Kidney Int. 64(5):1746-54 (2003).
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Zawadzki KM, Hamuro Y, Kim JS, Garrod S, Stranz DD, Taylor SS, Woods VL Jr.
Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS).
Protein Sci. 12(9):1980-90 (2003).
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Banky P, Roy M, Newlon MG, Morikis D, Haste NM, Taylor SS, Jennings PA.
Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform.
J Mol Biol. 330(5):1117-29 (2003).
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Zawadzki KM, Pan CP, Barkley MD, Johnson D, Taylor SS.
Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics. Proteins.
51(4):552-61 (2003).
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Burns LL, Canaves JM, Pennypacker JK, Blumenthal DK, Taylor SS.
Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA.
Biochemistry 42(19):5754-63 (2003).
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Hamuro Y, Zawadzki KM, Kim JS, Stranz DD, Taylor SS, Woods VL Jr.
Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS).
J Mol Biol. 327(5):1065-76 (2003)
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Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A.
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.
Proc Natl Acad Sci U S A. 100(7):4066-71 (2003).
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Burns-Hamuro LL, Ma Y, Kammerer S, Reineke U, Self C, Cook C, Olson GL, Cantor CR, Braun A, Taylor SS.
Designing isoform-specific peptide disruptors of protein kinase A localization.
Proc Natl Acad Sci U S A. 100(7):4072-7 (2003).
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Akamine P, Madhusudan, Wu J, Xuong NH, Ten Eyck LF, Taylor SS.
Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure.
J Mol Biol. 327(1):159-71 (2003).
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Moore MJ, Adams JA, Taylor SS.
Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop.
J Biol Chem. 278(12):10613-8 (2003).
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