Taylor Laboratory
Leichtag Biomedical
Research Building
4th Floor, Room 412
9500 Gilman Dr.
mail Code 0654
UC San Diego
La Jolla, CA 92093
Ph: (858) 534-8190
Fax: (858) 534-8193

Susan S. Taylor
Howard Hughes Medical Institute
Department of Chemistry and Biochemistry
Department of Pharmacology
University of California, San Diego
9500 Gilman Dr. CMM W 125
La Jolla, CA 92093-0654
Phone: 858 534-3677
Fax: 858 534-8193
1964 B.A. Chemistry, University of Wisconsin, Madison
1968 Ph.D. Physiological Chemistry, The John's Hopkins University, Baltimore, MD.
Postdoctoral Experience:  
1969-70 Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
1971-72 Postdoctoral Fellow, UC San Diego

Selected Publications

Eggers CT, Schafer JC, Goldenring JR, Taylor SS . D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. J Biol Chem. [Epub ahead of print] (2009). Pubmed

Kornev AP, Taylor SS , Ten Eyck LF. A helix scaffold for the assembly of active protein kinases. Proc Natl Acad Sci U S A. 105(38):14377-82 (2008). Pubmed pdf

Wu J, Brown SH, von Daake S, Taylor SS. PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science. 318(5848):274-9 (2007). Pubmed pdf

Kim C, Cheng CY, Saldanha SA, Taylor SS. PKA-I Holoenzyme Structure Reveals a Mechanism for cAMP-Dependent Activation. Cell. 130(6):1032-43 (2007). Pubmed pdf

Kannan N, Haste N, Taylor SS, Neuwald AF. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proc Natl Acad Sci U S A. 104(4):1272-7 (2007). Pubmed pdf

Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA, Taylor SS. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell. 24(3):397-408 (2006). Pubmed pdf

Kim C, Xuong NH, Taylor SS. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science. 307(5710):690-6 (2005). Pubmed pdf

Sastri M, Barraclough DM, Carmicheal PT, Taylor SS. A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci USA. 102(2):349-54 (2005). Pubmed pdf

Zhang J, Ma Y, Taylor SS, Tsien RY. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A.98(26):14997-5002(2001). Pubmed pdf

Su Y, Dostmann WR, Herberg FW, Durick K, Xuong NH, Ten Eyck L, Taylor SS, Varughese KI. Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science. 269(5225):807-13(1995). Pubmed

Wen W, Meinkoth JL, Tsien RY, Taylor SS. Identification of a signal for rapid export of proteins from the nucleus. Cell. 82(3):463-73(1995). Pubmed pdf

Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH,Taylor SS, Sowadski JM. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 253(5018):407-14(1991). Pubmed