Publications
2015

Keshwani, M.M., Kanter, J., Ma, Y., Wilderman, A., Darshi, M., Insel, P.A. and Taylor, S.S. Mechanisms of Cyclic AMP/Protein Kinase A- and Glucocorticoid-mediated Apoptosis in a Model System, S49 Lymphoma Cells. PNAS (2015). In Press

Kornev, A.P. and Taylor, S.S. Dynamics Driven Allostery in Protein Kinases. TIBS (2015). In Press

Mohanty, S., Kennedy, E.J., Herberg, F.W., Hui, R., Taylor, S.S, Langsley, G. and Kannan, N. Structure and Evolutionary Divergence of Cyclic Nucleotide Binding Domains in Eukaryotic Pathogens: Implications for Drug Design. BBA (2015). In Press

Antal, C.E., Callender, J.A., Kornev, A.P., Taylor, S.S. and Newton, A.C. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C bII. Cell Reports 12:1252-60 (2015). PMCID: PMC4551583

Wilderman, A., Guo, Y., Divakaruni, A., Perkins, G., Zhang, L., Murphy, A., Taylor, S.S. and Insel, P. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. JBC 290:22274-86 (2015).

Knape, M., Ahuja, L., Bertinetti, D., Burghardt, N., Zimmermann, B., Taylor, S.S. and Herberg, F. 

The Different Effects of the Divalent Metal Ions Mg2+ and Ca2+ on Protein Kinase A Activity and Regulation. Chem. Biol. (2015). In Press

Zhang, P., Ye, F., Bastidas, A.C., Kornev, A.P., Wu, J., Ginsberg, M.H. and Taylor, S.S. An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes. Structure 23:1563-72 (2015).

Gerlits, O., Tian, J., Das, A., Taylor, S.S., Langan, P., Heller, W.T. and Kovalevsky, A.  Phosphoryl Transfer Reaction Snapshots in Crystals: Insight into the Mechanism of Protein Kinase A Catalytic Subunit. JBC 290:15538-48 (2015). PMCID: PMC4505467

Malmstrom, R.D., Kornev, A.P., Taylor, S.S. and Amaro, R.E. Allostery through Conformational Selection: cAMP Regulation of the Cyclic-Nucleotide Binding Domain in PKA. Nature Comm. 6:7588 (2015). PMCID: PMC4504738

Zhang, P., Knape, M.J., Ahuja, L.G., Keshwani, M.M., King, C.C., Sastri, M., Herberg, F.W. and Taylor, S.S. Single Turnover Cycle of the PKA RIIb Holoenzyme. Plos Biol. 13(7):e1002192 (2015). PMCID: PMC4497662

Zhang, P., Kornev, A.P., Wu, J. and Taylor, S.S. Discovery of Allostery in PKA Signaling. Biophys. Rev. 7:227-238 (2015). PMCID: PMC4469037

Taylor, S.S and Kornev, A.P. PKA Signaling: Dynamic Assembly of Isoform-Specific Macromolecular Signalosomes. Biochem. Soc. Trans. (2015). In Press

Taylor, S.S., Shaw, A.S., Kannan, N. and Kornev, A.P. Integration of Signaling in the Kinome: Architecture and Regulation of the aC Helix. BBA 1854:1567-74 (2015).

Iglesias-Bartolome, R., Torres, D., Marone, R., Feng, X., Martin, D., Chen, M., Weinstein, L.S., Taylor, S.S, Molinolo, A.A. and Gutkind, J.S. A Gas-PKA Tumor Suppressor Pathway Restraining YAP1 and GLI in Stem Cells. NCB 17:793-803 (2015). PMCID: PMC4449815

Wei, S.C., Fattet, L., Tsai, J.H., Guo, Y., Pai, V.H., Majeski, H.E., Chen, A.C., Sah, R.L., Taylor, S.S., Engler, A.J. and Yang. Matrix Stiffness Drives Epithelial-Mesenchymal Transition and Tumor Metastasis via a Twist1-G3BP2 Mechanotransduction Pathway.  J. Nature Cell Biol. 17:678-88 (2015). PMCID: PMC4452027

McSkimming, D., Dastgheib, S., Katiyar, S., Talevich, E., Shaw, A.S., Taylor, S.S., Kochut, K., and Kannan, N. ProKinO: A Unified Resource for Mining the Cancer Kinome.  Hum. Mutat. 36: 175-86 (2015).

2014

Niyitegeka, J.-M. V., Bastidas, A.C., Newman, R.H., Taylor, S.S. and Ongeri, E.M. Isoform-specific Interactions between Meprin Metalloproteases and the Catalytic Subunit of Protein Kinase A: Significance in acute and chronic kidney injury. AJP Renal Physiol. 308:F56-68 (2014).

Sarma, G.N., Moody, I.S., Ilouz, R., Phan, R.H., Sankaran, B., and Taylor, S.S.  D-AKAP2-PKA RII-PDZK1 Ternary Complex Structure: Insights From the Nucleation of a Polyvalent Scaffold. Protein Sci. 24:105-16 (2014).

Hu, J., Ahuja, L.G., Meharena, H.S., Kannan, N., Kornev, A.P., Taylor, S.S. and Shaw, A.S.Kinase Regulation by Hydrophobic Spine Assembly in Cancer. MCB 35:264-276 (2015).

Srivastava, A.K., McDonald, L.R., Cembran, A., Kim, J., Materson, L.R., McClendon, C.L., Taylor, S.S. and Veglia, G. Synchronous Opening and Closing Motions are Essential for cAMP-dependent Protein Kinase A Signaling. Structure 22:59-69 (2014).

McClendon, C.L., Kornev, A.P., Gilson, M.K. and Taylor, S.S.The Dynamic Architecture of a Protein Kinase.  PNAS 111:E4623-31  (2014).

Boras, B., Kornev, A.P., Taylor, S.S. and McCulloch, A.Using Markov Models to Develop a Mechanistic Understanding of PKA-RIa Activation in Response to cAMP Binding.    JBC 289:30040-51 (2014).

Blumenthal, D.K., Copps, J., Smith-Nguyen, E.V., Zhang, P., Heller, W.T. and Taylor, S.S. The Roles of the RIIβ Linker and N-Terminal Cyclic Nucleotide Binding Domain in Determining the Unique Structures of the Type IIβ Protein Kinase A: A Small-Angle X-ray and Neutron Scattering Study.  J. Biol. Chem. (2014). 289:28505-12 (2014). 

Gerlits, O., Das, A., Keshwani, M., Taylor, S.S., Waltman, M.J., Heller, W., Langan, P. and Kovalevsky. Metal-free cAMP-dependent Protein Kinase can Catalyze Phosphoryl Transfer. A. Biochemistry 53:3179-86 (2014).

Pfanner, N., van der Laan, M., Amati, P., Capaldi, R.A., Caudy, A.A., Chacinska, A., Darshi, M., Deckers, M., Hoppins, S., Icho, R., Jakobs, S., Ji, J., Kozjak-Pavlovic, V., Meisinger, C. Odgren, P.R., Park, S.K., Rehling, P., Reichert, A.S., Seikh, M.S., Taylor, S.S., Tsuchida, N., van der Bliek, A.M., van der Klei, I.J., Weissman, J.S., Westermann, B., Zha, J., Neupert, W. and Nunnari, J. Uniform Nomenclature for the Mitochondrial Contact Site and Cristae Organizing System. J. Cell Biol. 204:1083-6 (2014).

Shaw, A.S., Kornev, A.P., Hu, J. Ahuja, L.G. and Taylor, S.S. Kinases and Pseudokinases: Lessons Learned from RAF.   Mol. Cell. Biol. 34:1538-46 (2014).

Akimoto, M., Moleschi, K., Boulton, S., Vanschouwen, B., Selvaratnam, R., Taylor, S.S and Melacini, G. Allosteric Linkers in cAMP Signaling.   Biochem. Soc. Trans. 42:139-44 (2014).

Bruystens, J.G.H., Wu, J., Fortezzo, A., Kornev, A.P., Blumenthal, D.K. and Taylor, S.S. PKA RIa Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease. Structure 22:59-69 (2014).

2013

Guo, Y., Darshi, M., Ma, Y., Perkins, G.A., Shen, Z., Haushalter, K.J., Saito, R., Chen, A., Lee, Y.S., Patel, H., Briggs, S.P., Ellisman, M.H., Olefsky, J.M. and Taylor, S.S. Quantitative Proteomic and Functional Analysis of Liver Mitochondria from High Fat Diet HFD) Diabetic Mice.   Mol. Cell. Proteomics 12:3744-58 (2013).

Brown, S.H.J., Cheng, C.Y., Saldanha, S.A., Wu, J., Cottam, H., Sankaran, B. and Taylor, S.S. Implementing High Throughput Fluorescence-based Screening and Crystallograhic Analysis for Selective Activation of Protein Kinase A RI and RII Holoenzymes by camp Analogs.   Chem. Biol. 8:2164-72 (2013).

Meharena, H.S., Chang, P., Keshwani, M., Oruganty, K., Kannan, N., Taylor, S.S. and Kornev, A.P. Deciphering the Molecular Anatomy of Eukaryotic Protein Kinase Activation.   Plos Biol. 11:21001680 (2013).

Okada, H., Lai, N.C., Kawaraguchi, Y., Liao, P., Copps, J., Sugano, Y., Okada-Maeda, S., Banerjee, I., Schilling, J.M., Gingras, A.R., Asfaw, E.K., Suarez, J., Kang, S.-M., Perkins, G.A., Au, C.G., Israeli-Rosenberg, S., Liu, Z., Milner, D.J., Kaufman, S.J., Patel, H.H., Roth, D.M., Hammond, H.K., Taylor, S.S., Dillmann, W.H., Goldhaber, J.I. and Ross, R.S. Integrins Protect Cardiomyocytesfrom Ischemia-reperfusion Injury and Bind RyR2.  J. Clin. Invest. 123:4294-308 (2013).

Bastidas, A., Pierce, Levi, Walker, R., Johnson, D. and Taylor, S.S. Influence of N-Myristylation and Ligand Binding on the Flexibility of the Catalytic Subunit of Protein Kinase A. Biochemistry 52:6368-79 (2013).

Akimoto, M.,  Selvaratnam, R., McNicholl, E.T., Verma, G., Taylor, S.S. and Melacini, G.Signaling through Dynamic Linkers as Revealed by PKA.   PNAS 110(35):14231-6 (2013).

Laanemets, K., Brandt, B., Li, J., Merilo, E., Wang, Y.-F., Keshwani, M., Taylor, S.S., Kollist, H. and Schroeder, J.I., Calcium-Dependent and -Independent Stomatal Signaling Network and Compensatory Feedback Control of Stomatal Opening via Ca2+ Sensitivity Priming.   Plant Physiol. 163:504-13 (2013).

Hu, J., Stites, E.C., Yu, H., Germino, E., Meharena, H.S., Tork, P.J.S., Kornev, A.P., Taylor, S.S. and Shaw, A.S.  Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers. Cell 154(5):1036-46 (2013).

Gerlits, O., Waltman, M.J., Taylor, S.S., Langan, P. and Kovalevsky, A.  Insights into the Phosphoryl Transfer Catalyzed by cAMP-dependent Protein Kinase:  an X-ray crystallographic study of complexes with various metals and peptide substrate SP20.   Biochemistry 52(21):3721-27 (2013).

Taylor, S.S., Shaw, A., Hu, J., Meharena, H.S. and Kornev, A.P.  Pseudokinase from a Structural Perspective. Biochem. Soc. Trans. 41(4):981-6 (2013).

Yu, F.X., Zhang, Y., Park, H.W., Jewell, J.L., Chen, Q., Deng, Y., Pan, D., Taylor, S.S., Lai, Z.C. and Guan, K.L.. Protein Kinase A Activates the Hippo Pathway to Modulate Cell Proliferation and Differentiation.   Genes Dev. 27(11):1223-32 (2013).

Taylor, S.S., Zhang, P., Steichen, J.M., Keshwani, M.M., and Kornev, A.P. PKA: Lessons Learned after Twenty Years.   Biochim. Biophys. Acta 1834:1271-78 (2013).

Lee, Y.S., Morinaga, H., Kim, J.J., Lagakos, W., Taylor, S.S., Keshwani, M., Perkins, G., Dong, H., Kayali, A.G., Sweet, I.R., and Olefsky, J. The Fractalkine and CX3CR1 System Regulates Beta Cell Function and Insulin Secretion. Cell 153:413-25 (2013). 

Bastidas, A.C., Deal, M.S., Steichen, J.M., Guo, Y., Wu, J., and Taylor, S.S. Phosphoryl Transfer by Protein Kinase A is Captured in a Crystal Lattice. JASC 135: 4788-98 (2013).

2012

Sastri, M., Haushalter, K. J., Panneerselvam, M., Chang, P., Fridolfsson, H., Finley, J.C., Ng, D., Schilling, J.M., Miyanohara, A., Day, M.E., Hakozaki, H., Petrosyan, S., Koller, A., King, C.C., Darshi, M., Blumenthal, D., Ali, S.S., Roth, D.M., Patel, H.H. and Taylor, S.S.A Kinase Interacting Protein (AKIP1) is a Key Regulator of Cardiac Stress.   PNAS 110(5):E387-96 (2012).

Cembran, A., Masterson, L.R., McClendon, C.L., Taylor, S.S., Gao, J., and Veglia, G. Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Moelucular Dynamics Simulations.   Biochemistry 51(51):10186-96 (2012).

Xu, X., Keshwani, M., Sarikas, A., Taylor, S.S., and Pan, Z.Q. Identification of the Degradation Determinants of Insulin Receptor Substrate 1 for Signaling Cullin-RING E3 Ubiquitin Ligase 7-Mediated Ubiquitination.   JBC 287(48):40758-66 (2012).

Guo, Y., Wilderman, A., Zhang, L., Taylor, S.S., and Insel, P.A. Quantitative Proteomics Analysis of the cAMP/Protein Kinase A (PKA) Signaling Pathway in S49 Lymphoma Cells. Biochemistry 51(46):9323-32 (2012).

Darshi, M., Trinh, N.K., Murphy, A.N., and Taylor, S.S.Targeting and Import Mechanism of ChChd3 into the Mitochondrial Inter Membrane Space.   JBC 287(47):39480-91 (2012).

Burgers, P.P., Ma, Y., Margarucci, L., Mackey, M., van der Heydon, M.A., Ellisman, M., Scholten, A., Taylor, S.S., and Heck, A.J. A Small Novel A-Kinase Anchoring Protein (AKAP) That Localizes Specifically Protein Kinase A-Regulatory Subunit I (PKA-RI)to the Plasma Membrane. JBC 287(52):43789-97 (2012).

Taylor, S.S., Ilouz, R., Zhang, P., and Kornev, A.P. Assembly of Allosteric Macromolecular Switches: Lessons from PKA.  Nat. Rev. Mol. Cell Biol. 13:646-58 (2012).

Kukrer, B., Barbu, I.M., Copps, J., Hogan, P., Taylor, S.S., van Duijn, E., Heck, A.J.R. Conformational Isomers of Calcineruin Follow Distinct Dissociation Pathways. JASMS 23:1534-43(2012).

Kovalevsky, A., Johnson, H., Hanson, L., Waltman, M.J., Fisher, Z., Taylor, S.S. and Langan, P.  Low-and Room-temperature X-ray Structures of Protein Kinase A Ternary Complexes Shed new Light on Its Activity. Acta Crystallogr. D Biol. Crystallogr. 68(Pt7):854-60 (2012).

Abrahamsen, H., O'Neill, A.K., Kannan, N., Kruse, N., Taylor, S.S., Jennings, P.A. and Newton, A.C. The Peptidyl-prolyl Isomerase Pin1 Controls the Down-regulation of Conventional Protein Kinase C Isozymes. JBC 287(16):13262-78 (2012).

Ilouz, R., Bubis, J., Wu, J., Yim, Y.Y., Deal, M., Kornev, A., Ma, Y., Blumenthal, D. and Taylor, S.S. Localization and Quaternary Structure of the PKA RIb Holoenzyme.  PNAS 109(31):12443-8(2012).

Bastidas, A.C., Deal, M.S., Steichen, J.M., Keshwani, M.M., Guo, Y., and Taylor, S.S. Role of N-Terminal Myristylation in the Structure and Regulation of cAMP-Dependent Protein Kinase. JMB 422:215-229 (2012).

Taylor, S.S., Keshwani, M.M., Steichen, J.M., and Kornev, A.P. Evolution of the Eukaryotic Protein Kinases as Dynamic Molecular Switches. Philos Trans R Soc Lond B Biol Sci 367(1602):2517-28 (2012).

Haste, N.M., Talabani, H., Doo, A., Merckx, A., Langsley, G., Taylor, S.S. Exploring the Plasmodium Falciparum cyclic-adenoise Monophosphate 9cAMP)-dependennt Protein Kinase (PfPKA) as a Therapeutic Target. Microbes & Infections 14:838-50 (2012).

Keshwani, M.M., Klammt, C., von Daake, S., Ma, Y., Kornev, A.P., Choe, S., Insel, P.A. and Taylor, S.S.  Cotranslational cis-phosphorylation of the COOH-terminal Tail is a Key Priming Step in the Maturation of cAMP-dependent Protein Kinase. PNAS 109(20):E1221-9 (2012).

Zhang, P., Smith-Nguyen, E.V., Keshwani, M.M. Deal, M.S., Kornev, A.P. and Taylor, S.S.  Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme. Science 335:712-716 (2012). Pubmed

Taylor, S.S. & Kornev, A.P. PKA:  Prototype for Dynamic Signaling in Time & Space. Quantitative Biology: From Molecular to Cellular Systems, Chapman & Hall/CRC Mathematical & Computational Biology, ed Wall, M.E (Boca Raton, London, New York: CRC Press) pg. 267-298 (2012).

Steichen, J., Kuchinskas, M., Keshwani, M.M., Yang, J., Adams, J.A. and Taylor, S.S.Structural Basis for the Regulation of Protein Kinase A by Activation Loop Phosphorylation.   JBC 287(18):14672-80 (2012).

Yang, J., Wu, J., Steichen, J.M., Kornev, A.P., Deal, M.S., Li., S., Sankaran, B., Woods Jr., V.L. and Taylor, S.S.  A Conserved Glu-Arg Salt Bridge Connects Co-evolved Motifs That Define the Eukaryote Protein Kinase Fold. JMB 415(4):666-79(2012).

2011

Thompson, E.E, Taylor, S.S. and McCammon, J.A. Protein Kinases:  Phosphorylation Machines. Molecular Machines edited by Benoit Roux pg. 115-130 (2011).

Means, C.K., Lygren, B., Langeberg, L.K, Jain, A., Dixon, R.E., Vegal, A.L., Gold, M.G., Petrosyan, S. Taylor, S.S., Murphy, A.N., Ha, T., Santana, L.F., Tasken, K. and Scott, J.D. An Entirely Specific Type-I A-kinase Anchoring Protein That Can Sequester Two Molecules of Protein Kinase A at Mitochondria.  PNAS 108:E1227-35 (2011).

Osborne, B.W., Wu, J., McFarland, C.J., Nickl, C.K., Sankaran, B., Casteel, D.E., Woods, Jr., V.L., Kornev, A.P., Taylor, S.S., and Dostmann, W.R.  Crystal Structure of cGMP-dependent Protein Kinase Reveals Novel Site of Interchain Communication. Structure 19:1317-1327 (2011).

King, C.C., Sastri, M., Chang, P., Pennypacker, J., and Taylor, S.S. The Rate of NF-kB Nuclear Translocation is Rgulated by PKA and A Kinase Interacting  Protein 1.   PLoS 6:1-15 (2011).

Keshwani, M.M., von Daake, S., Newton, A.C., Harris, T.L., Taylor, S.S. Hydrophobic Motif Phosphorylation is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1).  JBC 286:23552-58 (2011).

Masterson, L.R., Shi, L., Metcalfe, E., Gao, J., Taylor, S.S. and Veglia, G. Dynamically Committed, Uncommitted, and Quenched States Encoded in Protein Kinase A Revealed by NMR Spectroscopy.   PNAS 108:6969-6974 (2011).

Hu, J., YU, H., Kornev, A.P., Zhao, J., Filbert, E.L., Taylor, S.S., and Shaw, A.S. Mutation That Blocks ATP Binding Creates a Pseudokinase Stabilizing the Scaffolding Function of Kinase Suppressor of Ras, CRAF and BRAF. PNAS 108:6067-6072 (2011).

Day, M.E., Gaietta, G.M., Sastri, M., Koller, A., Mackey, M.R., Scott, J.D., Perkins, G.A., Ellisman, M.H., and Taylor, S.S.  Isoform Specific Targeting of PKA to Multivesicular Bodies. JCB 193:347-363 (2011).

Boettcher, A.J., Wu, J., Yang, K.C., Bruystens, J., Cheung, N., Pennypacker, J.K., Blumenthal, D.A. Kornev, A.P., Taylor, S.S.  Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIa Holoenzymes. Structure 19:265-76 (2011).

Darshi, M., Macke, M.R., Murphy, A.N., Koller, A., Perkins, G.A., Ellisman, M.H., Taylor, S.S. ChChd3, an Inner Mitochondrial Membrane Protein, is Essential for Maintaining Cristae Integrity and Mitochondrial Function.   JBC 286:2918-32  (2011).

Taylor, S.S. and Kornev, A.P. Protein Kinases:  Evolution of Dynamic Regulatory Proteins.     TIBS Review 36:65-77 (2011).

 

2010

Badireddy, S., Yunfeng, G., Ritchie, M., Akamine, P., Wu, J., Kim, C.W., Taylor, S.S., Qingsong, L., Swaminathan, K., Anand. G.S. Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design. Mol Cell Proteomics 10(3)M110-00-4390:1-14 (2010).

McLaughlin, W.A., Hou, T., Taylor, S.S., Wang, W. The Identification of Novel cyclic AMP-dependent Protein Kinase Anchoring Proteins using Bioinformatic Filters and Peptide Arrays. Protein Engineering, Design & Selection (PEDS) 24:333-339 (2010).

Patel, H.H., Hamuro, L.L., Chun, B.J., Kawaraguchi, Y., Quick, A., Rebolledo, B., Pennypacker, J., Thurston, J., Rodriquez-Pinto, N., Self, C., Olson, G. Insel, P.A., Giles, W.R., Taylor, S.S., Roth, D.M.  Disruption of Protein Kinase A Localization Using a Trans-activator of Transcription (TAT)-conjugated A-kinase-anchoring Peptide Reduces Cardiac Function.    JBC 285:27632-40 (2010).

Masterson, L.R., Cheng, C., Yu, T., Tonelli, M., Kornev, A. Taylor, S.S., Veglia. G. Dynamics Connect Substrate Recognition to Catalysis in Protein Kinase A. Nat Chem Biol 6:821-8 (2010).

Anand, G.S., Krishnamurthy, S., Bishnoi, T., Kornev, A., Taylor, S.S., Johnson, D.A. Cyclic-AMP and Rp-cAMPS Induced Conformational Changes in a Complex of the Catalytic and Regulatory (RIa) Subunits of PKA. Molecular & Cellular Proteomics 10:2225-37 (2010).

McNicholl, E.T., Das, R., SilDas, S., Taylor, S.S., Melacini, G. Communication Between Tandem cAMP Binding Domains in the Regulatory Subunit of Protein Kinase A-1a as Revealed by Domain-silencing Mutations.   JBC 285:15523-37 (2010).

Sjoberg, T.J., Kornev, A.P., Taylor, S.S.  Dissecting the cAMP-inducible Allosteric Switch in Protein Kinase A RIa. Protein Science 19:1213-21 (2010).

Sarma, G.N., Kinderman, F.S., Kim, C., von Daake, S., Chen, L., Wang, B., Taylor, S.S.Structure of D-AKAP2-PKA RI Isoform Complex:  Insights Into AKAP Specificity and Selectivity. Structure 18:155-66 (2010).

Taylor, S.S., Kornev, A.P. Yet Another “Active” Pseudokinase, Erb3. PNAS 107:8047-48 (2010).

Steichen, J.M., Iyer, G.H., Li, S., Saldanha, S. A., Deal, M.S., Woods, V.L., Taylor, S.S.  Global Consequences of Activation Loop Phosphorylation on Protein Kinase A. JBC 285:3825-32 (2010).

Kornev, A.P., Taylor, S.S.  Defining the Conserved Internal Architecture of a Protein Kinase. BBAPAP 1804:440-44 (2010).

 

2009

Cheng, C.Y., Yang, J., Taylor, S.S., Blumenthal, D.K. Sensing Domain Dynamics in PKA-1a Complexes by Solution X-ray Scattering. JBC 284:35916-25 (2009).

Eggers, C.T., Schafer, J.C., Goldenring, J.R., Taylor, S.S. D-AKAP2 Interacts with Rab4 and Rab11 Through Its RGS Domains and Regulates Transferrin Receptor Recycling.  JBC 284:32869-80 (2009).

Khavrutskii, I.V., Grant, B., Taylor, S.S., McCammon, J.A. A Transition Path Ensemble Study Reveals a Linchpin Role for Mg2+ during Rate-Limiting ADP Release from Protein Kinase A. Biochemistry 48:11532-45 (2009).

Brown, S.H.J., Wu, J., Kim, C.W., Alberton, K., & Taylor, S.S. Novel Isoform-Specific Interfaces Revealed by PKA RIIb Holoenzyme Structures.  J. Mol Biol 393:1070-1082 (2009).

Taylor, S.S. & Radzio-Andzaelm-E. cAMP-Dependent Protein Kinase.  Handbook of Cell Signaling 2nd Edition.  Oxford:Academic Press:1461-1470 (2009).

Thompson, E.E., Kornev, A.P., Kannan, N., Kim, C., Ten Eyck, L.F., Taylor, S.S. Comparative Surface Geometry of the Protein Kinase Family.   Protein Science 18:2016-2026 (2009).

Romano, R.A., Kannan, N., Kornev, A.P., Allison, C.J., Taylor, S.S. A Chimeric Mechanism for Polyvalent Trans-phosphorylation of PKA by PDK1.  Protein Science 18:1486-97 (2009).

Contribution of Non-catalytic Core Residues to Activity and Regulation in PKA.  Yang, J., Kennedy, E.J., Deal, M.S., Pennypacker, J., Ghosh, G., Taylor, S.S.  JBC 284:6241-6248 (2009).

Kennedy, E.J., Yang, J., Pillus, L., Taylor, S.S., Ghosh, G.  Identifying Critical Non-Catalytic Residues that Modulate Protein Kinase A Activity.  PLoS 4:1-7 (2009).

Gould, C.M., Kannan, N., Taylor, S.S., Newton, A.C. The Chaperones HSP90 and CDC37 Mediate the Maturation and Stabilization of Protein Kinase C Through a Conserved PXXP Motif in the C-terminal Tail. JBC 284:4921-4935 (2009).

Kornev, A.P., Taylor, S.S.  Pseudokinases:  Functional Insights Gleaned from Structure. Structure 17:5-7 (2009)..

2008

Kornvev, A.P., Taylor, S.S., Ten Eyck, L.F. A Helix Scaffold for the Assembly of Active Protein Kinases. PNAS 105:14377-14382 (2008).

Torkamani, A., Kannan, N., Taylor, S.S., Schork, N. Congenital Disease SNPs Target Lineage Specific Structural Elements in Protein Kinases. PNAS 105:9011-9106 (2008).

Kornev, A.P., Taylor, S.S., Ten Eyck, L.F. A Generalized Allosteric Mechanism for cis-Regulated Cyclic Nucleotide Binding Domains.   PLoS 4:1-9 (2008).

Ma, Y. and Taylor,  S.S.  A Molecular Switch for Targeting Between ER and Mitochondria:  Conversion of a Mitochondria-Targeting Element into an ER-Targeting Signal in DAKAP1. JBC 283:11743-51(2008).

Kannan, N., Taylor, S.S.  Rethinking Pseudokinases. Cell 133:1-2 (2008).

Masterson, L.R., Mascioni, A., Traaseth, N.J., Taylor, S.S., Veglia, G. Allosteric Cooperativity in Protein Kinase A.   PNAS 105:506-11 (2008).

2007

Ten Eyck, L.F., Taylor, S.S., Kornev A.P.Conserved Spatial Patterns Across the Protein Kinase Family.   Biochimica et Biophysica Acta1784:238-243(2007) (Invited Article).

Kannan, N., Neuwald, A.F., Taylor, S.S.  Analogous Regulatory Sites Within the aC-b4 Loop Regions of ZAP-70 Tyrosine Kinase and AGC Kinases. Biochimica et Biophysica Acta1784:27-32(2008).

Taylor, S.S., Kim, C.W., Cheng, C.Y., Brown, S.H., Wu, J., Kannan, N. Signaling through cAMP and cAMP-dependent Protein Kinase: Diverse Strategies for Drug Design. Biochimica et Biophysica Acta 1784:16-26 (2008).

Kannan, N., Wu, J., Anand, G.S., Yooseph, S., Neuwald, A.F., Venter, J.C., Taylor, S.S. Evolution of Allostery in the Cyclic Nucleotide Binding Module. Genome Biology 8:R264.1-R264.13 (2007).

Valiev, M., Yang J., Adams, J. Taylor, S.S., Weare, J.H. Phosphorylation Reaction in cAPK Protein Kinase-Free Energy Quantum Mechanical/Molecular Mechanics Simulations. Journal of Physical Chemistry111:13455-13464(2007).

Taylor, S.S., Eggers, C.T., Kim, C. Multivalent Integration of Local and Global Signaling through PKA, Calcineurin, AKAP79/150, and L-Type Calcium Channels.   Cellscience 4:ISSN 1742-8130 (2007).

Anand, G.S., Hotchko, M., Brown, S.H.J., Ten Eyck, L.F., Komives, E.A., Taylor, S.S. R-subunit Isoform Specificity in Protein Kinase A: Distinct Features of Protein Interfaces in PKA Types I and II by Amide H/2H exchange mass Spectrometry.  JMB 374:487-499 (2007).

Wu, J., Brown, S.H. J., von Daake, S., Taylor, S.S. PKA Type IIa Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity. Science 318:274-279(2007).

Alto, N.M., Weflen, A.W., Rardin. M.J., Yarar, D., Lazar, C.S., Tonikian, R., Koller, A., Taylor, S.S., Boone, C., Sidhu, S.S., Schmid, S.S., Hecht, G.A., Dixon, J.E. The Type III Effector EspF Coordinates Membrane Trafficking by the Spatiotemporal Activation of Two Eukaryotic Signaling Pathways.  Journal of Cell Biology 178:1265-1278 (2007).

Martin, B.R., Deerinck, T.J., Ellisman, M.H., Taylor, S.S., Tsein, R.  Isoform-Specific PKA Dynamics Revealed by Dye-Triggered Aggregation and DAKAP1a- Mediated Localization in Living Cells.  Chemistry & Biology 14:1031-42 (2007).

Kim, C., Cheng, C.Y., Saldanha, A.S., Taylor, S. S.PKA-Ia Holoenzyme Structure Reveals a Mechanism for cAMP-dependent Activation.   Cell 130:1032-43 (2007).

Anand, G., Taylor, S.S., Johnson, D.A.  Cyclic-AMP and Pseudosubstrate Effects on Type-I A-kinase Regulatory and Catalytic Subunit Binding Kinetics. Biochemistry 46:9283-9291(2007).

Navarro, L., Koller, A., Nordfelth, R., Wolf-Watz, H., Taylor, S.S., Dixon, J.E. Identification of a Molecular Target for the Yersinia Protein Kinase A.  Molecular Cell 26:465-477 (2007).

Humphries, K.M., Pennypacker, J.K., and Taylor S.S.  Redox Regulation of PKA Signaling: Kinase Versus Phosphatase Inactivation.  JBC 282:22072-9 (2007).

Schauble, S., King, C.C., Darshi, M., Koller, A., Shah, K., Taylor, S.S. Identification of ChChd3 as a Novel Substrate of the cAMP-dependent Protein Kinase (PKA) Using an Analog-sensitive Catalytic Subunit. J. Biol. Chem., 282:14952-9 (2007).

Lim, C.J., Han, J., Yousefi, N., Ma, Y., Amieux, P.S., McKnight, G.S., Taylor, S.S., Ginsberg, M.H. a4 Integrins are Type I cAMP-dependent Protein Kinase-anchoring Proteins.  J. Biol. Chem., 282:22079-9 (2007).

Kannan, N., Haste, N., Taylor, S.S., and Neuwald, A.F. The Hallmark of AGC Kinase Functional Divergence is its C-terminal Tail, a cis-acting Regulatory Module.  PNAS 104:1272-1277 (2007).

Kannan, N., Taylor, S.S., Zhai, Y., Venter, C.J., and Manning, G.  Structural & Functional Diversity of the Microbial Kinome. PLoS Biology 5:1-35 0467-0478 (2007).

Yooseph, S., Sutton, G., Rusch, D.B., Halpern, A.L., Williamson, S.J., Remington, K., Eisen, J.A., Heidelberg, K.B., Manning, G., Li, W., Jaroszewski, L., Cieplak, P., Miller, C.S., Li, H., Mashiyama, S.T., Joachimiak, M.P., vanBelle, C., Chandonia, J.M., Soergel, D.A., Zhai, Y., Natarajan , K., Lee, S., Raphael, B.J., Bafna, V., Friedman, R., Brenner, S.,E. Godzik, A., Eisenberg, D., Dixon, J.E., Taylor, S.S., Strausberg, R.L., Frazier, M., Venter,  J.C. The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families.PLoS Biology 5:1-35(2007).

2006

Saldanha, S.A., Kaler, G., Cottam, H.B., Abagyan, R., Taylor, S.S. Assay Principle for Modulators of Protein-Protein Interactions and its Application to non-ATP-Competitive Ligands Targeting Protein Kinase A.  Analytical Chemistry 78: 8265-8272 (2006).

Das, R., Esposito, V., Abu-Abed, M., Anand, G., Taylor, S.S., Melacini, G. cAMP Activation of PKA Defines an Ancient Signaling Mechanism. Proc. Natl. Acad. Sci. USA 104:93-98 (2006).

Taylor, S.S. and Ghosh, G. Protein Kinases: Catalysis and Regulation. Current Opinion in Structural Biology 16:665-667 (2006).

Kornev, A.P., Haste, N.M., Taylor, S.S., Ten Eyck, L.F.  Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanism. Proc. Natl. Acad. Sci. 103: 17783-17788 (2006).

Kinderman, F., Kim, C., von Daake, S., Ma, Y., Pham, B., Spraggon, G., Xuong, N., Jennings, P.A., Taylor, S.S. A Dynamic Mechanism for AKAP Binding to RII Isoforms of cAMP-dependant Protein Kinase. Molecular Cell 24: 397-408 (2006).

Cranston, A.N., Carniti, C., Oakhill, K., Radzio-Andzelm, E., Stone, E.A., McCallion, A.A., Hodgson, S., Clarke, S., Mondellini, P., Leyland, J., Pierotti, M.A., Whittaker, J., Taylor, S.S., Bongarzone, I., Ponder, B.A.J.  RET Is Constitutively Activated by Novel Tandem Mutations That Alter the Active Site Resulting in Multiple Endocrine Neoplasia Type 2B. Cancer Research 66:10179-10187 (2006).

Veronica Esposito, Tim Sjoberg, Rahul Das, Simon Brown, Susan S. Taylor and Giuseppe Melacini.  Letter to the Editor: 1H, 15N, and 13C Chemical Shift Assignments of the cAMP-Binding Domain A of the PKA Regulatory Subunit.  J. Biomol NMR 36: 64 (2006).

Kim, C., Vigil, D., Anand, G. and Taylor, S.S.  Structure and Dynamics of PKA Signaling Proteins. European Journal of Cell Biology 85:651-654(2006).

Neidner, R.H., Buzko, O.V., Haste, N.M., Taylor, A. Gribskov, M., and Taylor, S.S. Protein Kinase Resource: an integrated environment for phosphorylation research.  Proteins: Structure, Function, and Bioinformatics  63:78-86(2006).

Vigil, D., Blumenthal, D.K., Taylor, S.S. and Trewhella, J. Solution Scattering Reveals Large Differences in the Global Structures of Type II Protein Kinase A Isoforms.  JMB 357:880-889(2006).

Gullingsrud, J., Kim, C., Taylor, S.S., and McCammon, J.A. Dynamic Binding of PKA Regulatory Subunit RIa. Structure 14:141-149 (2006).

Vigil, D., Lin, J-H., Sotriffer, C.A., Pennypacker, J.K., McCammon, J.A. and Taylor, S.S. A Simple Electrostatic Switch Important in the Activation of Type I Protein Kinase A by Cyclic AMP.   Protein Science 15:113-121 (2006).

2005

Taylor, S.S., Kim, C.W., Vigil, D., Haste, N. and Yang,  J.  Dynamics of Signaling by PKA. Biochimica et Biophysica Acta 1754:25-37 (2005).

Burns-Hamuro, L.L., Hamuro, Y., Kim, J.S., Sigala, P., Fayos, R., Stranz, D.D., Jennings, P.A., Taylor, S.S., and Woods Jr., V.L.   Distinct Interaction Modes of an AKAP Bound to Two Regulatory Subunit Isoforms of PKA Revealed by Amide Hydrogen/Deuterium Exchange. Protein Science 14:1-11 (2005).

Wu, J., Yang, J., Kannan, N., Madhusudan, Xuong, N-H., Ten Eyck, L.F., Taylor, S.S. Crystal Structure of the E230Q Mutant of cAMP-dependent Protein Kinase Reveals an Unexpected Apoenzyme Conformation and an Extended N-terminal A Helix.   Protein Science 14:2871-79 (2005).

Vigil, D., Blumenthal, D.K., Taylor, S.S., and Trewhella,  J. The Conformationally Dynamic C Helix of the RIa-Subunit of Protein Kinase A Mediates Isoform Specific Domain Reorganization Upon C Subunit Binding.  J. Biol.  Chem. 280:35521-35527(2005).

Zhang, J., Hupfeld, C.J., Taylor, S.S., Olefsky, J.M., and Tsien, R.Y. Insulin Disrupts Beta-Adrenergic Signaling to Protein Kinase A. Nature 437:569-573 (2005).

Taylor, S.S., Haste, N.M. and Ghosh, G. PKR and elF2a:  Integration of Kinase Dimerization, Activation, and Substrate Docking. Cell 122:823-834 (2005).

Iyer, G., Garrod, S., Woods Jr., V.L., and Taylor, S.S.Catalytic Independent Functions of a Protein Kinase as Revealed by a Kinase-dead Mutant:  Study of the Lys72His Mutant of c-AMP Dependent Kinase.  J. Mol. Biol. 351:1110-1122 (2005).

Iyer, G., Moore, M., and Taylor, S.S. Consequences of Lysine 72 Mutation on the Phosphorylation and Activation state of PKA.  J. Biol. Chem 280:8800-8807 (2005).

Kim, C.W., Xuong, Ng. H., and Taylor, S.S. Crystal Structure of a Complex Between the Catalytic and Regulatory (RIa) Subunits of PKA. Science 307:690-696 (2005).

Yang, J., Garrod, S., Deal, M.S., Anand, G., Woods Jr., V.L., Taylor, S.S. Allosteric Network of cAMP-Dependent Protein Kinase Revealed by Mutation of Tyr 204 in the P+1 loop. J. Mol. Biol. 346:191-201(2005).

Humphries, K. M., Deal, M.S., and Taylor, S.S. Enhanced Dephosphorylation of cAMP-Dependent Protein Kinase  by Oxidation and Thiol Modification.   J.Biol. Chem. 280:2750-2758 (2005).

Sastri, M., Barraclough, D.M., Carmichael, P.T., and Taylor, S.S. A-kinase-interacting Protein Localizes Protein Kinase A in the Nucleus.   Proc. Natl. Acad. Sci. USA. 102:349-354(2005).

Berman, H.M., Ten Eyck, L.F., Goodsell, D.S., Haste, N.M., Kornev, A. and Taylor, S.S.The cAMP Binding Domain:  An Ancient Signaling Module. Proc. Natl. Acad. Sci. USA 102:45-40 (2005).

2004

Buzko, O., Niedner, H., Haste, N., Taylor, A., Gribskov, M., and Taylor, S.S. The Protein Kinase Resource.   12th International Conference on Second Messengers and Phosphoproteins. MedimondS.r.lE803C0263:87-92 (2004).

Nolen B, Taylor, S.S., and Ghosh, G. Regulation of Protein Kinases:  Controlling Activity through Activation Segment Conformation. Molecular Cell 15:1-20(2004).

Wu, J., Brown, S., Xuong, Ng. H., and Taylor, S.S. RIa Subunit of PKA: A cAMP-free Structure Reveals a Hydrophobic Capping Mechanism for Docking cAMP into Site B. Structure 12:1057-1065 (2004).

Vigil, D., Blumenthal,  D.K., Brown, S. Taylor, S.S., Trewhella, J. Differential Effect of Substrate Binding on Type I and Type II PKA Holoenzyme Dissociation. Biochemistry 43:5629-5636 (2004).

Hamuro, Y., Anand, G.S., Kim, J.S., Juliano, C., Stranz, D.D., Taylor, S.S., and Woods Jr., V.L. Mapping Intersubunit Interactions of the Regulatory Subunit (RIa) in the Type I Holoenzyme of Protein Kinase A by Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS). J. Mol. Biol. 340:1185-1196 (2004).

Heller, W.T., Vigil, D.,Brown, S., Blumenthal, D.K., Taylor, S.S., and Trewhella,   J. C Subunits Binding to the Protein Kinase RIa Dimer Induce a Large Conformational Change. J. Biol. Chem. 279:19084-19090 (2004).

Vigil, D., Blumenthal, D.K., Heller, W.T., Brown, S., Cànaves,  J.M.,  Taylor, S. S., and Trewhella,   J . Conformational Differences Among Solution Structures of the Type Ia, IIa and IIb Protein Kinase A Regulatory Subunit Homodimers:  Role of the Linker Regions. J. Mol. Biol. 337:1183-1194(2004).  

Wu, J., Jones, J.M., Xuong, Ng. H., Ten Eyck, L.F., and Taylor, S.S. Crystal Structures of RIa Subunit of Cyclic Adenosine 5’-monophosphate (cAMP)-dependent Protein Kinase Complexed with (Rp)-adenosine 3’,5’-cyclic Monophosphothioate and (Sp)-adenosine 3’,5’-cyclic Monophosphothioate, the  Phosphothioate Analogues of  cAMP. Biochemistry 43 (21), 6620 -6629 (2004).

Burns-Hamuro, L., Barraclough, D.M., and Taylor, S. S. Identification and Functional Analysis of Dual-Specific A-Kinase Anchoring Protein-2 (D-AKAP2). Methods of Enzymology  390:354-374 (2004).

Taylor, S.S., Yang, J., Wu, J., Haste, N.M., Radzio-Andzelm, E., and Anand, G.  PKA: a Portrait of Protein Kinase Dynamics. Biochim. Biophys. Acta.  1697:259-269 (2004).

Zawadzki, K. M. and Taylor, S.S.  cAMP-dependent  Protein Kinase  Regulatory Subunit Type IIb: Active Site Mutations Define an Isoform-Specific Network for Allosteric Signaling by cAMP. J. Biol. Chem. 279:7029-7036 (2004).

Yang, J., Ten Eyck, L.F., Xuong, Ng. H., and Taylor, S.S.  Crystal Structure of a cAMP-dependent Protein Kinase Mutant at 1.26 Å: New Insights into the Catalytic Mechanism. J. Mol. Biol. 336:473-487 (2004). 

Akamine, P., Madhusudan,  Brunton, L.L., Ou, H.D., Cànaves, J.M., Xuong, Ng. H., and Taylor, S.S.  Balanol Analogues Probe Specificity Determinants and the Conformational Malleability of the Cyclic 3’,5’-adenosine Monophosphate-dependent Protein Kinase Catalytic Subunit.Biochemistry  43: 85-96 (2004).

2003

Anand, G.S., Law, D., Mandell, J.G., Snead, A.N., Tsigelny, I., Taylor, S.S., Ten Eyck, L.F., and Komives, E.A. Identification of the Protein Kinase A Regulatory RIa-Catalytic Subunit Interface by Amide H/2H Exchange and Protein Docking. Proc. Natl. Acad. Sci., USA. 100: 13264-13269(2003).

PDZK1: II. An Anchoring Site for the PKA-binding Protein DAKAP2 in Renal Proximal Tubular Cells.  Gisler, S.M., Madjdpour, C., Pribanic, D.S. Bacic, D., Taylor, S.S.,Biber, J., and Murer, H.  Kidney International  64:1746-1754  (2003).

Zawadzki,  K.M., Hamuro, Y., Kim, J. S., Garrod, S.M., Stranz, D.D., Taylor, S.S., and Woods Jr., V.L. Dissecting Interdomain Communication Within cAPK Regulatory Subunit Type IIb Using Enhanced Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS). Protein Science 12:1980-1990 (2003).

Radzio-Andzelm,  E. and Taylor, S.S. cAMP-dependent Protein Kinase. Handbook of Cell Signaling (Invited Paper, 2003).

Banky, P., Roy, M., Newlon, M.G., Morikis, D., Haste, N.M., Taylor, S.S., and Jennings, P.A.Related Protein-Protein Interaction Modules Present Drastically Different Surface Topographies Despite a Conserved Helical Platform. J. Mol. Biol. 330:1117-1129 (2003).

Burns, L.L., Cànaves, J.M., Pennypacker, J.K., Blumenthal, D.K., and Taylor, S.S. Isoform Specific Differences in Binding of a Dual-Specificity A-Kinase Anchoring Protein to Type I and Type II Regulatory Subunits of PKA. Biochemistry 42:5754-5763 (2003).

Hamuro, Y., Zawadzki, K.M., Kim, J.S., Stranz, D.D., Taylor, S.S., and  Woods Jr., V.L. Dynamics of cAPK Type IIb Activation Revealed by Enhanced Amide H/2H Exchange Mass Spectrometry (DXMS). J. Mol. Biol. 327(5):1065-1076 (2003).

Burns-Hamuro,  L.L., Ma,  Y., Kammerer,  S.,  Reineke, U.,  Self, C., Cook,  C., Olson,  G.L., Cantor,  C.R., Braun, A.,  and Taylor, S.S. Designing Isoform-Specific Peptide Disruptors of Protein Kinase A Localization.  Proc. Natl. Acad. Sci. USA 100:4072-4077 (2003).

Moore, M., Adams, J.A., and Taylor, S.S. Structural Basis for Peptide Binding in Protein Kinase A: Role of Glutamic Acid 203 and Tyrosine 204 in the Peptide-Positioning Loop. J. Biol. Chem. 278:10613-10618 (2003).

Akamine, P., Madhusudan, Wu, J., Xuong, Ng. H., Ten Eyck, L.F, and Taylor, S.S. Dynamic Features of cAMP-dependent Protein Kinase Revealed by Apoenzyme Crystal Structure.   J. Mol. Biol. 327:159-171(2003).

Zawadzki, K.M., Pan, C., Barkley, M.D., Johnson, D.A., and Taylor, S.S. Endogenous Tryptophan Residues of cAPK Regulatory Subunit Type IIb Reveal Local Variations in Environments and Dynamics.  Zawadzki, K.M., Pan, C., Barkley, M.D., Johnson, D.A., and Taylor, S.S.  Proteins 51:552-561 (2003).

2002

Chatterji, A., Burns, L. L., Taylor, S.S., Lomonossoff, G. P., Johnson, J. E., Lin, T., and Porta, C. Cowpea Mosaic Virus: From the Presentation of Antigenic Peptides to the Display of Active Biomaterials. Intervirology 45:362-370 (2002).

Moore, M.J., Kanter, J.R., Jones, K.C., and Taylor, S.S. Phosphorylation of the Catalytic Subunit of Protein Kinase A:  Autophosphorylation vs. Phosphorylation by Phosphoinositide-dependent-kinase-1. J. Biol. Chem. 277:47878-47884 (2002).

Humphries, K.M., Juliano, C., and Taylor, S.S. Regulation of cAMP-dependent Protein Kinase Activity by Glutathionylation.  J. Biol. Chem.  277:43505-43511 (2002).

Anand, G.S., Hughes, C.A., Jones, J.M., Taylor, S.S., and Komives, E.A. Amide H/2H Exchange Reveals Communication Between the cAMP and Catalytic Subunit-Binding Sites in the RIa Subunit of Protein Kinase A. J. Mol. Biol. 323:377-386 (2002).

Hamuro, Y., Burns, L.L., Cànaves , J.M., Hoffman, R.C., Taylor, S.S., and Woods Jr., V.L.  Domain Organization of D-AKAP2 Revealed by Enhanced Deuterium Exchange-Mass Spectrometry (DXMS). J. Mol. Biol. 321:703-714 (2002).

Ma, Y. and Taylor, S.S.  A 15-Residue Bi-Functional Element in DAKAP1 is Required for Both ER and Mitochondrial Targeting. J. Biol. Chem.  2:27328-27336 (2002).

Madhusudan, Akamine, P., Xuong, Ng. H., and Taylor, S.S.  Crystal Structure of a Transition State Mimic of the Catalytic Subunit of cAMP-dependent Protein Kinase. Nat. Struct. Biol. 9:273-277 (2002).

Li, F., Gangal,  M., Juliano, C., Gorfain, E., Taylor, S.S., and Johnson, D.A. Evidence for an Internal Entropy Contribution to Phosphoryl Transfer: A Study of Domain Closure, Backbone Flexibility, and the Catalytic Cycle of cAMP-dependent Protein Kinase.  J. Mol. Biol. 315:459-469 (2002).

Cànaves,  J.M. and Taylor, S.S.Classification and Phylogenetic Analysis of cAMP-dependent Protein Kinase Regulatory Subunit Family. J. Mol. Evol. 54:17-29 (2002).

2001

Perkins, G.A., Wang, L., Huang, L.J., Humphries, K., Yao, V.J., Martone, M., Deerinck, T.J., Barraclough, D.M., Violin, J.D., Smith D., Newton, A., Scott, J.D., Taylor, S.S., and Ellisman, M.H. PKA, PKC and AKAP Localization In and Around the Neuromuscular Junction.  BMC Neuroscience 2:17 (2001).

Zhang, J., Ma, Y., Taylor, S.S., and Tsien, R.Y. Genetically Encoded Reporters of Protein Kinase A Activity Reveal Impact of Substrate Tethering. Proc. Natl. Acad. Sci. USA 98:14997-15002 (2001).

Johnson, D. A., Akamine, P., Radzio-Andzelm, E., Madhusudan, and Taylor, S.S.  Dynamics of cAMP-dependent Protein Kinase. Chemical Reviews  101:2243-2270 (2001).

Wong, C.F., Hunenberger, P.H., Akamine, P., Narayana, N., Diller, T., McCammon, J.A., Taylor, S.S., and Xuong, Ng. Computational Analysis of PKA-Balanol Interactions.  H. J. Med. Chem. 44:1530-1539 (2001).

Wang, L., Sunahara, R., Krumins, A., Perkins, G., Crochiere, M.L., Mackey, M., Bell, S., Ellisman, M., and Taylor, S.S. Cloning and Mitochondrial Localization of Full Length d-AKAP2, a Protein Kinase A Anchoring Protein. Proc. Natl. Acad. Sci. USA 98:3220-3225 (2001).

Diller, T.C., Madhusudan, Xuong, Ng. H., and Taylor, S.S. Molecular Basis for Regulatory Subunit Diversity in cAMP-dependent Protein Kinase: Crystal Structure of the Type IIb Regulatory Subunit.Structure 9:73-82 (2001).

Cheng, X., Phelps, C., and Taylor, S.S. Differential Binding of cAMP-dependent Protein Kinase Regulatory Subunit Isoforms Ia and IIb to the Catalytic Subunit. J. Biol. Chem. 276:4102-4108 (2001).

2000

Herrgård, S., Jambeck, P., Taylor, S.S., and Subramaniam, S. Domain Architecture of a Caenorhabditis elegans AKAP Suggests a Novel AKAP Function.  FEBS Letters 486:107-111 (2000).

Cànaves,  J.M., Leon, D.A., and Taylor, S.S.  Consequences of cAMP-binding Site Mutations on the Structural Stability of the Type I Regulatory Subunit of cAMP-dependent Protein Kinase. Biochemistry 39:15022-15031 (2000).

Li, F., Gangal, M., Jones, J.M., Deich, J., Lovett, K.Ee. Taylor, S.S., and Johnson, D.A.  Consequences of cAMP and Catalytic-subunit Binding on the Flexibility of the A-Kinase Regulatory Subunit. Biochemistry 39:15626-15632 (2000).

Banky, P., Newlon, M.G., Roy, M., Garrod, S., Taylor, S.S., and Jennings, P.A.  Isoform-specific Differences Between the Type Ia and IIa Cyclic AMP-dependent Protein Kinase Anchoring Domains Revealed by Solution NMR. J. Biol. Chem. 275:35146-35152 (2000).

Diller, T.C., Xuong, Ng. H., and Taylor, S.S.  Type IIb Regulatory Subunit of cAMP-dependent Protein Kinase:  Purification Strategies to Optimize Crystallization. Protein Expression and Purification 20:357-364 (2000).

Aimes, R., Hemmer, W., and Taylor, S.S. Serine-53 at the Tip of the Glycine-Rich Loop of the cAMP-dependent Protein Kinase:  Role in Catalysis, P-Site Specificity, and Interaction with Inhibitors. Biochemistry 39:8325-8332 (2000).

Setyawan,  J., Koide, K., Diller, T.C., Bunnage, M.E., Taylor, S.S., Nicolaou, K.C., and Brunton, L.L.  Inhibition of Protein Kinases by Balanol:  Specificity Within the Serine/Threonine Protein Kinase Subfamily. Molecular Pharmacology  56:370-376 (2000).

Leon, D., Cànaves, J., and Taylor, S. S.  Probing the Multidomain Structure of the Type I Regulatory Subunit of cAMP-dependent Protein Kinase Using Mutational Analysis:  Role and Environment of Endogenous Tryptophans. Biochemistry 39:5662-5671 (2000).

Zaccolo, M., De Giorgi, F., Cho, C.Y., Feng, L., Knapp, T., Negulescu, P.A., Taylor, S.S., Tsien, R.Y., and Pozzan, T.   A Genetically Encoded, Fluorescent Indicator for cyclic AMP in Living Cells. Nature Cell Biology  2:25-29 (2000).

1999

Gangal, M., Clifford, T., Deich, J., Cheng, X., Taylor, S.S., and Johnson, D.A. Mobilization of the A-Kinase N-Myristate Through an Isoform-Specific Intermolecular Switch. Proc. Natl. Acad. Sci. USA 96:12394-12399 (1999).

Tsigelny, I., Greenberg, T., Cox, S., Nichols, W., Taylor, S.S., and Ten Eyck, L.F. 600 PS Molecular Dynamics Reveals Stable Sub Structures and Flexible Hinge Points in cAMP- dependent Protein Kinases. Biopolymers 50:513-524 (1999).

Taylor, S.S., Radzio-Andzelm, E., Madhusudan, Cheng, X., Ten Eyck, L.F., and Narayana, N.  Catalytic Subunit of Cyclic AMP-dependent Protein Kinase: Structure and Dynamics of the Active Site Cleft. Pharmacol. Ther. 82:133-141 (Invited paper 1999).

Huang, L. J., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T.J., Ellisman, M.H., and Taylor, S.S. NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase-anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum. J. Cell Biol. 145:951-959 (1999).

Hauer, J.A., Taylor, S.S., and Johnson, D.A.  Binding-dependent Disorder-order Transition in PKIa: A Fluorescence Anisotropy Study. Biochemistry 38:6774-6780 (1999).

Herberg, F.W., Doyle, M.L., Cox, S., and Taylor, S.S.  Dissection of the Nucleotide and Metal-Phosphate Binding Sites in cAMP-dependent Protein Kinase. Biochemistry 38:6352-6360 (1999).

Harada, H., Becknell, B., Wilm, M., Mann, M., Huang, L. J., Taylor, S.S., Scott, J. D., and Corsmeyer, S. J.  Phosphorylation and Inactivation of BAD by Mitochondrial-Anchored Protein Kinase A. Molecular Cell 3:413-422 (1999).

Smith, C.M., Radzio-Andzelm, E., Madhusudan, Akamine, P., and Taylor, S.S. The Catalytic Subunit of cAMP-dependent Protein Kinase: Prototype for an Extended Network of Communication. Progress in Biophysics &  Molecular Biology  71:313-341 (Invited paper 1999).

Hauer, J.A., Barthe, P., Taylor, S.S., Parello, J., and Padille, A.  Two Well-Defined Motifs in the cAMP-dependent Protein Kinase Inhibitor (PKIa) Correlate with Inhibitory and Nuclear Export Function. Protein Science  8:545-553 (1999).

Narayana, N., Diller, T., Koide, K., Nicolaou II, K.C., Brunton, L.L., Xuong, Ng. H., Ten Eyck, L.F., and Taylor, S.S.  Crystal Structure of the Potent Natural Product Inhibitor Balanol in Complex with the Catalytic Subunit of cAMP-dependent Protein Kinase. Biochemistry 38:2367-2376 (1999).

Hünenberger, P.H., Helms, V., Narayana, N., Taylor, S.S., and McCammon, A.  Determinants of Ligand Binding to cAMP-dependent Protein Kinase. Biochemistry 38:2358-2366 (1999).

1998

Narayana, N., Akamine, P., Xuong, Ng. H., and Taylor, S.S.  Crystallization and Preliminary X-ray Analysis of the Unliganded Recombinant Catalytic Subunit of cAMP-dependent Protein Kinase. Acta Cryst.  D54:1401-1404 (1998).

Banky, P., Huang, L.J., and Taylor, S.S. Dimerization/Docking Domain of the Type Ia Regulatory Subunit of cAMP-dependent Protein Kinase:  Requirements for Dimerization and Docking are Distinct but Overlapping. J. Biol. Chem. 273:35048-35055 (1998).

Struppe, J., Komives, E.A., Taylor, S.S., and Vold, R.R.   2H NMR Studies of a Myristoylated Peptide in Neutral and Acidic Phospholipid Bicelles. Biochemistry 37:15523-15527 (1998).

Gangal, M., Cox, S., Lew, J., Clifford, T., Garrod, S.M., Aschbaher, M., Taylor, S.S., and Johnson, D.A. Backbone Flexibility of Five Sites on the Catalytic Subunit of cAMP-dependent Protein Kinase in the Open and Closed Conformations. Biochemistry 37:13728-13735 (1998).

Cheng, X., Shaltiel, S., and Taylor, S.S.  Mapping Substrate-Induced Conformational Changes in cAMP-dependent Protein Kinase by Protein Footprinting. Biochemistry 37:14005-14013 (1998).

Huang, L.J. and Taylor, S.S.  Dissecting cAMP Binding Domain A in the RI a Subunit of cAMP-dependent Protein Kinase: Distinct Subsites for Recognition of cAMP and the Catalytic Subunit. J. Biol. Chem.  273:26739-26746 (1998).

Cheng, X., Ma, Y., Moore, M., Hemmings, B., and Taylor, S.S. Phosphorylation and Activation of cAMP-dependent Protein Kinase by Phosphoinositide-dependent Protein Kinase. Proc. Nat. Acad. Sci. USA 95:9849-9854 (1998).

de Lecea, L., Criado, J., Rivera, S., Wen, W., Soriano, E., Henriksen, S., Taylor, S.S., Gall, C., and Sutcliffe, J. G.Endogenous Protein Kinase A Inhibitor (PKIa) Modulates Synaptic Activity. J. Neuroscience Research  53:269-278 (1998).

Grant, B.D., Hemmer, W., Tsigelny, I., Adams, J.A., and Taylor, S.S.  Kinetic Analyses of Mutations in the Glycine-Rich Loop of a cAMP-dependent Protein Kinase. Biochemistry 37:7708-7715  (1998).

Durick, K., Gill, G.N., and Taylor S.S.  Shc and Enigma are Both Required for Mitogenic Signaling by Ret/ptc2. Mol. Cell. Biol. 18:2298-2308 (1998).

Shaltiel, S., Cox, S., and Taylor, S.S.  Conserved Water Molecules Contribute to the Extensive Network of Interactions at the Active Site of Protein Kinase A. Proc. Nat. Acad. Sci. USA 95:484-491 (1998).

1997

Gibson, R. and Taylor, S.S.  Dissecting the Cooperative Reassociation of the Regulatory and Catalytic Subunits of cAMP-dependent Protein Kinase:  Role of Trp196 in the Catalytic Subunit. J. Biol. Chem. 272:31998-32005 (1997).

Yonemoto, W., McGlone, M.L., and Taylor, S.S.  Autophosphorylation of the Catalytic Subunit of cAMP-dependent Protein Kinase in E. coli. Protein Engineering 10:915-925 (1997).

Leon, D., Herberg, F.W., Banky, P., and Taylor, S.S.  A Stable a-Helical Domain at the N-terminus of the RIa Subunits of cAMP-dependent Protein Kinase is a Novel Dimerization/Docking Motif. J. Biol. Chem. 272:28431-28437 (1997).

Huang, L.J., Durick, K., Weiner, J.A., Chun, J., and Taylor, S.S.  D-AKAP2, A Novel Protein Kinase A Anchoring Protein with a Putative RGS Domain. Proc. Nat. Acad. Sci. USA 94:11184-11189 (1997).

Narayana, N., Cox, S., Xuong, Ng. H., Ten Eyck, L.F., and Taylor, S.S.  A Binary Complex of the Catalytic Subunit of cAMP-dependent Protein Kinase and Adenosine Further Defines Conformational Flexibility. Structure 5:921-935 (1997).

Gibson, R.M., Ji-Buechler, Y., and Taylor, S.S.  Identification of Electrostatic Interaction Sites Between the Regulatory and Catalytic Subunits of Cyclic AMP-dependent Protein Kinase. Protein Science 6:1825-1834 (1997).

Radzio-Andzelm,  E. and Taylor, S.S.  Protein Kinase Inhibition:  Natural and Synthetic Variations on a Theme. Current Opinion in Chemical Biology 1:219-226 (1997).

Gibson, R.M., Ji-Buechler, Y., and Taylor, S.S.  Interaction of the Regulatory and Catalytic Subunits of cAMP-dependent  Protein Kinase:  Electrostatic Sites on the Type Ia Regulatory Subunit. J. Biol. Chem. 272:16343-16350 (1997).

Lew, J., Taylor, S.S., and Adams, J.A. Identification of a Partially Rate-Determining Step in the Catalytic Mechanism of cAMP-dependent Protein Kinase:  A Transient Kinetic Study Using Stopped-Flow Fluorescence Spectroscopy. Biochemistry 36:6717-6724 (1997).

Hemmer, W., McGlone, M.L., and Taylor, S.S.  The Role of the Glycine Triad in the ATP-binding Site of cAMP-dependent Protein Kinase. J. Biol. Chem. 272:16946-16954 (1997).

Narayana, N., Cox, S., Shaltiel, S., Taylor, S.S., and Xuong, Ng. H. Crystal Structure of the Poly-Histidine Tagged Recombinant Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with the Peptide Inhibitor PKI(5-24) and Adenosine. Biochemistry 36:4438-4448 (1997).

Huang, L.J., Durick, K., Weiner, J.A., Chun, J., and Taylor, S.S.  Identification of a Novel Protein Kinase A Anchoring Protein that Binds Both Type I and Type II Regulatory Subunits.  J. Biol. Chem. 272:8057-8064 (1997).

Herberg, F., Zimmermann, B., McGlone, M., and Taylor, S.S.  Importance of the A-helix of the Catalytic Subunit of cAMP-dependent Protein Kinase for Stability and for Orienting Subdomains at the Cleft Interface. Protein Science  6:569-579 (1997).

Hemmer, W., McGlone, M., and Taylor, S.S.  Recombinant Strategies for Rapid Purification of Catalytic Subunits of cAMP-dependent Protein Kinase. Analytical Biochemistry  245:115-122 (1997).

Padilla, A., Hauer, J., Tsigelny, I., Parello, J., and Taylor, S.S.  Solution Structure of Synthetic Peptide Inhibitor and Substrate of cAMP-dependent Protein Kinase. J. Peptide Res. 49:210-220 (1997).

Lew, J., Tsigelny, I., Coruh, N., and Taylor, S.S. Synergistic Binding of Nucleotides and Inhibitors to cAMP-dependent Protein Kinase Examined by Acrylodan Fluorescence Spectroscopy.  J. Biol. Chem. 272:1507-1513 (1997).

1996

Wu, R., Durick, K., Songyang, Z., Cantley, L.C., Taylor, S.S., and Gill, G.N.  Specificity of LIM Domain Interactions with Receptor Tyrosine Kinases. J. Biol. Chem. 271:15934-15941 (1996).

Chestukhin, A., Litovchick, L., Schourov, D., Cox, S., Taylor, S.S., and Shaltiel, S.  Functional Malleability of the Carboxyl-terminal Tail in Protein Kinase A.  J. Biol. Chem271:10175-10182 (1996).

Grant, B.D., Taylor, S.S., Tsigelny, I., and Adams,  J.A. Examination of an Active-Site Electrostatic Node in cAMP-dependent Protein Kinase Catalytic Subunit.   Protein Science 5:1316-1324 (1996).

Durick, K., Wu, R., Gill, G.N., and Taylor, S.S.  Mitogenic Signaling by Ret/ptc2 Requires Association with Enigma Via a LIM Domain. J. Biol. Chem. 271:12691-12694 (1996).

Tsigelny,  I., Grant, B.D., Taylor, S.S., and Ten Eyck, L.F.  Catalytic Subunit of cAMP-dependent Protein Kinase:  Electrostatic Features and Peptide Recognition. Biopolymers 39:353-365 (1996).

1995

Herberg, F.W., Taylor, S.S., and Dostmann, W.R.G.  Active Site Mutations Define the Pathway for the Cooperative Activation of cAMP-dependent Protein Kinase. Biochemistry 35:2934-2942 (1995).

Radzio-Andzelm, E., Lew,  J., and Taylor, S.S.  Bound to Activate: Conformational Consequences of Cyclin Binding to CDK2. Structure 3:1135-1141 (1995).

Koide, K., Bunnage, M.E., Paloma, L. G., Taylor, S.S., Brunton, L., and Nicolaou, K.C.  Molecular Design and Biological Activity of Potent and Selective Protein Kinase Inhibitors Related to Balanol. Chemistry and Biology 2:601-608 (1995).

Cox, S. and Taylor, S. S.  Kinetic Analysis of cAMP-dependent Protein Kinase:  Mutations at Histidine 87 Affect Peptide Binding and pH Dependence. Biochemistry 34:16203-16209 (1995).

Durick, K., Yao, V.J., Borrello, M.G., Boonarzone, I., Pierotti, M.A., and Taylor, S.S. Tyrosines outside the Kinase Core and Dimerization are Required for the Mitogenic Activity of RET/ptc2. J. Biol. Chem. 270:24642-24645 (1995).

Taylor, S.S., Radzio-Andzelm, E., and Hunter, T.  How do Protein Kinases Discriminate Between Serine/Threonine and Tyrosine?  Structural Insights from the Insulin Receptor Protein-Tyrosine Kinase. FASEB  9:1255-1266 (1995).

Su, Y., Dostmann, W.R.G., Herberg, F.W., Durick, K., Xuong, Ng. H., Ten Eyck, L.F., Taylor, S.S., and Varughese, K.I.  Regulatory Subunit of Protein Kinase A:  Structure of Deletion Mutant with cAMP Binding Domains. Science 269:807-813 (1995).

Wen, W., Meinkoth, J.L. Tsien, R.Y., and Taylor, S.S.  Identification of a Signal for Rapid Export of Proteins from the Nucleus. Cell 82:463-473 (1995).

Armstrong, A., Wen, W., Meinkoth, J., Taylor, S.S., and Montminy, M.  A Refractory Phase In cAMP Responsive Transcription Requires Down Regulation of Protein Kinase A. Mol. Cell Biol.  15:1826-1832 (1995).

Adams, J.A., McGlone, M.L., Gibson, R., and Taylor, S.S.  Phosphorylation Modulates Catalytic Function and Regulation in the cAMP-dependent Protein Kinase. Biochemistry 34:2447-2454 (1995).

Wen, W., Taylor, S.S., and Meinkoth, J.L.  The Expression and Intracellular Distribution of the Heat Stable PKI is Cell Cycle Regulated. J. Biol. Chem. 270:2041-2046 (1995).

1994

Taylor, S.S. and Radzio-Andzelm, E.  cAMP-dependent Protein Kinase. In Frontiers in Molecular Biology:  Protein Kinases  (Eds. J. Woodgett), Oxford University Press, Toronto (1994).

Cox, S., Radzio-Andzelm,  E., and Taylor, S.S. Domain Movements in Protein Kinases. Curr. Opin. Struct.  Biol. 4:893-901 (1994).

Wen, W., Harootunian, A.T., Adams, S., Feramisco, J., Tsien, R.Y., Meinkoth, J.L., and Taylor, S.S.  Heat Stable Protein Kinase Inhibitors of cAMP-dependent Protein Kinase Carry a Nuclear Export Signal. J. Biol. Chem. 269:32214-32220 (1994).

Solberg, R., Tasken, K., Wen, W., Coghlan, V.M., Meinkoth, J.L., Scott, J.D., Jahnsen, T., and Taylor, S.S.  Human Regulatory Subunit RIb of cAMP-dependent Protein Kinases:  Expression, Holoenzyme Formation and Microinjection into Living Cells. Experimental Cell Research 214:595-605 (1994).

Veron, M., Radzio-Andzelm, E., Tsigelny, I., and Taylor, S.S.  Protein Kinases Share a Common Structural Motif Outside the Conserved Catalytic Domain.  Cell Mol. Biol. 40:587-596 (1994).

Cox, S. and Taylor, S.S.Holoenzyme Interaction Sites in the cAMP-dependent Protein Kinase:  Histidine 87 in the Catalytic Subunit Complements Serine 99 in the Type I Regulatory Subunit. J. Biol. Chem. 269:22614-22622 (1994).

Karlsson, R., Taylor, S.S., and Sowadski, J.M.  Intermolecular Contacts in Various Crystal Forms Related to the Open and Closed Conformation States of the Catalytic Subunit of cAMP-dependent Protein Kinase. Acta Cryst. D50:657-662 (1994).

Herberg, F.W., Dostmann, W.R.G., Zorn, M., Davis, S.J., and Taylor, S.S. Crosstalk Between Domains in the Regulatory Subunit of cAMP-dependent Protein Kinase:  Influence of Amino Terminus on cAMP-binding and Holoenzyme Formation.   Biochemistry 33:7485-7494 (1994).

Taylor, S. S. and Radzio-Andzelm,  E.Three Protein Kinase Structures Define A Common Motif. Structure 2:345-355 (1994).

Madhusudan, Trafny, E.A., Xuong, Ng. H., Adams, J.A., Ten Eyck, L.F., Taylor, S.S., and Sowadski, J.M.  cAMP-dependent Protein Kinase:  Crystallographic Insights into Substrate Recognition and Phosphostransfer. Protein Science 3:176-187 (1994).

Wen, W. and Taylor, S.S.  High Affinity Binding of the Heat Stable Protein Kinase Inhibitor to the Catalytic Subunit of cAMP-dependent Protein Kinase Is Selectively Abolished by Mutation of Arg133. J. Biol. Chem. 269:8423-8430 (1994).

Fantozzi, D.A., Harootunian, A.T., Wen, W., Taylor, S.S., Feramisco, J.R., Tsien, R.Y., and Meinkoth, J.L. Thermostable Inhibitor of cAMP-dependent Protein Kinase Enhances the Rate of Export of the Kinase Catalytic Subunit from the Nucleus. J. Biol. Chem. 269:2676-2686 (1994).

1993

Taylor, S.S. cAMP-dependent Protein Kinase:  Framework for the Protein Kinase Family. Yokohama Med. Bull. 34 (1993).

Meinkoth, J.L., Alberts, A.S., Wen, W., Fantozzi, D., Taylor, S.S., Hagiwara, M., Montminy, M., and Feramisco, J.R.  Signal Transduction Through the cAMP-dependent Protein Kinase. Mol. Cell. Biochem.  127/128:179-186 (1993).

Taylor, S.S., Radzio-Andzelm, E., Knighton, D.R., Ten Eyck, L.F., Sowadski, J.M., Herberg, F.W., Yonemoto, W., and Zheng, J.  Crystal Structures of the Catalytic Subunit of cAMP-dependent Protein Kinase Reveal General Features of the Protein Kinase Family. Receptor 3:Chap. 3, 165-172. G. Litwack, Ed. (Humana Press, Inc., Totowa, NJ) (1993).

Herberg, F.W. and Taylor, S.S.  Physiological Inhibitors of the Catalytic Subunit of cAMP-dependent Protein Kinase:  Effect of MgATP on Protein/Protein Interaction. Biochemistry 32:14015-14022 (1993).

Adams, J.A. and Taylor, S.S.  Divalent Metal Ions Influence Catalysis and Active-Site Accessibility in the cAMP-dependent Protein Kinase. Protein Science 2:2177-2186 (1993).

Harootunian, A.T., Adams, S.R., Wen, W., Meinkoth, J.L., Taylor, S.S., and Tsien, R.Y.  Movement of the Free Catalytic Subunit of cAMP-dependent Protein Kinase into and out of the Nucleus Can Be Explained by Diffusion. Mol. Biol. Cell 4:993-1002 (1993).

Veron, M., Radzio-Andzelm, E., Tsigelny, I., Ten Eyck, L.F., and Taylor, S.S.  A Conserved Helix Motif Complements the Protein Kinase Core. Proc. Nat. Acad. Sci. USA  90:10618-10622 (1993).

Herberg, F.W., Bell, S.M., and Taylor, S.S.  Expression of the Catalytic Subunit of cAMP-dependent Protein Kinase in E. coli:  Multiple Isozymes Reflect Different Phosphorylation Sites. Protein Engineering 6:771-777 (1993).

Adams, S. Bacskai, B., Harootunian, A.T., Mahaut-Smith, M., Sammak, P.J., Taylor, S.S., and Tsien, R.Y.  Imaging of cAMP Signals and A-Kinase Translocation in Single Living Cells.  In Advances in Second Messenger and Phosphoprotein Research, 28:Chap. 21, B.L. Brown and P.R.M. Dobson, Eds. (Raven Press, Ltd., New York), p. 167-170 (1993).

Tasken, K., Skålhegg, B.S., Soldberg, R., Andersson, K.B., Taylor, S.S., Lea, T., Blomhoff, H.K., Janson, T., and Hansson, V.  Novel Isozymes of cAMP-dependent Protein Kinase Exist in Human Cells Due to Formation of RIa-RIb Heterodimeric Complexes. J. Biol. Chem. 268:21276-21283 (1993).

Zheng, J., Knighton, D.R., Xuong, Ng. H., Taylor, S.S., Sowadski, J.M., and Ten Eyck, L.F.  Crystal Structures of the Myristylated Catalytic Subunit of cAMP-dependent Protein Kinase Reveal Open and Closed Conformations. Protein Science 2:1559-1573 (1993).

Karlsson, R., Zheng, J., Xuong, Ng. H., Taylor, S.S., and Sowadski, J.M.  The Crystal Structure of Mammalian Catalytic Subunit of cAMP-dependent Protein Kinase and a Di-iodinated PKI(5-24) Inhibitor Peptide Displays an Open Conformation. Acta Cryst. D49:381-388(1993).

Marcote, M.J., Knighton, D.R., Basi, G., Sowadski, J.M., Brambilla, P., Draetta, G., and Taylor, S.S.  A Three-dimensional Model of the Cdc2 Protein Kinase:  Identification of Cyclin and Suc1 Binding Regions. Mol. Cell. Biol. 13:5122-5131 (1993).

Yonemoto, W., Garrod, S.M., Bell, S.M., and Taylor, S.S.  Identification of Phosphorylation Sites in the Recombinant Catalytic Subunit of cAMP-dependent Protein Kinase. J. Biol. Chem. 268: 18626-18632 (1993).

Buechler, Y.J., Herberg, F.W., and Taylor, S.S.  Regulation Defective Mutants of Type I cAMP-dependent Protein Kinase:  Consequences of Replacing Arg94 and Arg95. J. Biol. Chem. 268:16495-16503 (1993).

Taylor, S.S., Zheng, J., Radzio-Andzelm, E., Knighton, D.R., Ten Eyck, L.F., Sowadski, J.M., Herberg, F.W., and Yonemoto, W. cAMP-dependent Protein Kinase Defines a Family of Enzymes.  Phil. Trans. R. Soc. Lond. B 340:315-324 (1993).

Knighton, D.R., Cadena, D.L., Zheng, J., Ten Eyck, L.F., Taylor, S.S., Sowadski, J.M., and Gill, G.N.  Structural Features that Specify Tyrosine Kinase Activity Deduced from Homology Modeling of the EGF Receptor. Proc. Nat. Acad. Sci. USA 90:5001-5005 (1993).

Adams, S.R., Bacskai, B.J., Taylor, S.S., and Tsien, R.Y. Optical Probes for Cyclic AMP.  In Fluorescent and Luminescent Probes for Biological Activity — A Practical Guide to Technology for Quantitative Real-Time Analysis. W. T. Mason, Ed. Academic Press Chap. 10,133-149 (1993).

Zheng, J., Trafny, E.A., Knighton, D.R., Xuong, Ng. H., Taylor, S.S., Ten Eyck, L.F., and Sowadski, J.M.  2.2 Å Refined Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with MnATP and a Peptide Inhibitor. Acta Cryst. D49:362-365 (1993).

Knighton, D.R., Bell, S.M., Zheng, J., Ten Eyck, L.F., Xuong, Ng. H., Taylor, S.S., and Sowadski, J.M.  2.0 Å Refined Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with a Peptide Inhibitor and Detergent. Acta Cryst. D49:357-361 (1993).

Adams, J.A. and Taylor, S.S.  Phosphorylation of Peptide Substrates for the Catalytic Subunit of cAMP-dependent Protein Kinase. J. Biol. Chem. 268:7747-7752 (1993).

Su, Y., Taylor, S.S., Dostmann, W.R.G., Xuong, Ng. H., and Varughese, K.I. Crystallization of a Deletion Mutant of the R-subunit of cAMP-dependent Protein Kinase. J. Mol. Biol. 230:1091-1093 (1993).

Taylor, S.S., Knighton, D.R., Zheng, J., Sowadski, J.M., Gibbs, C.S., and Zoller, M.J.  A Template for the Protein Kinase Family. Trends in Biochemical Sciences 18:84-89 (1993).

Zheng, J., Knighton, D.R., Ten Eyck, L.F., Karlsson, R., Xuong, Ng. H., Taylor, S.S., and Sowadski, J.M.  Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase Complexed with MgATP and Peptide Inhibitor. Biochemistry 32:2154-2161 (1993).

Yonemoto, W., McGlone, M.L., and Taylor, S.S.  N-Myristylation of the Catalytic Subunit of cAMP-dependent Protein Kinase Conveys Structural Stability. J. Biol. Chem. 268:2348-2352 (1993).

1992

Mann, S.K.O., Yonemoto, W.M., Taylor, S.S., and Firtel, R.A. DdPK3, Which Plays Essential Roles During Dictyostelium Development, Encodes the Catalytic Subunit of cAMP-dependent Protein Kinase. Proc. Nat. Acad. Sci. USA  89:10701-10705 (1992).

Toner-Webb, J., van Patten, S.M., Walsh, D.A., and Taylor, S.S.  Autophosphorylation of the Catalytic Subunit of cAMP-dependent Protein Kinase. J. Biol. Chem. 267:25174-25180 (1992).

Taylor, S.S., Knighton, D.R., Zheng, J., Ten Eyck, L.F., and Sowadski, J.M. cAMP-dependent Protein Kinase and the Protein Kinase Family.  In Faraday Discussion (Royal Society of Chemistry), 93:143-152 (1992).

Knighton, D.R., Pearson, R.B., Sowadski, J.M., Means, A.R., Ten Eyck, L.F., Taylor, S.S., and Kemp, B.E.  Structural Basis of the Intrasteric Regulation of Myosin Light Chain Kinases. Science 258:130-135 (1992).

Taylor, S.S. and Adams, J.A.  Protein Kinases: Coming of Age. Current Opinion in Structural Biology 2:743-748 (1992).

Taylor, S.S., Knighton, D.R., Zheng, J., Ten Eyck, L.F., and Sowadski, J.M.  Structural Framework for the Protein Kinase Family. Annu. Rev. Cell Biol. 8:429-462 (1992).

Adams, J.A. and Taylor, S.S.  The Energetic Limits of Phosphotransfer in the Catalytic Subunit of cAMP-dependent Protein Kinase as Measured by Viscosity Experiments. Biochemistry 31: 8516-8522 (1992).

Fantozzi, D.A., Taylor, S.S., Howard, P.W., Maurer, R.A., Feramisco, J.R., and Meinkoth, J.L.  Effect of the Thermostable Protein Kinase Inhibitor on Intracellular Localization of the Catalytic Subunit of cAMP-dependent Protein Kinase. J. Biol. Chem. 267:16824-16828 (1992).

Zheng, J., Knighton, D.R., Xuong, Ng. H., Parello, J., Taylor, S.S., and Sowadski, J.M. Crystallization Studies of the Catalytic Subunit of cAMP-dependent Protein Kinase:  Crystals of Murine Recombinant Catalytic Subunit and a Mutant, Cys 343 -->Ser, Diffract to 2.7Å Resolution. Acta Cryst. B48:241-244 (1992).

Gibbs, C.S., Knighton, D.R., Sowadski, J.M., Taylor, S.S., and Zoller, M.J.  Systematic Mutational Analysis of cAMP-dependent Protein Kinase Identifies Unregulated Catalytic Subunits and Defines Regions Important for the Recognition of the Regulatory Subunit. J. Biol. Chem. 267: 4806-4812 (1992).

1991

Yonemoto, W., McGlone, M.L., Slice, L.W., and Taylor, S.S.  Prokaryotic Expression of the Catalytic Subunit of cAMP-dependent Protein Kinase. Methods In Enzymology (Eds., T. Hunter and B.M. Sefton), 200:581-596 (1991).

Zheng, J., Knighton, D.R., Parello, J., Taylor, S.S., and Sowadski, J.M.  Crystallization of the Catalytic Subunit of cAMP-dependent Protein Kinase. Methods In Enzymology (Eds., T. Hunter and B.M. Sefton), 200:508-521 (1991).

Buechler, J.A., Toner-Webb, J., and Taylor, S.S.  Carbodiimides as Probes for Protein Kinase Structure and Function. Methods In Enzymology (Eds., T. Hunter and B.M. Sefton),  200:487-500 (1991).

Dostmann, W.R.G. and Taylor, S.S.  Identifying the Molecular Switches that Determine Whether (Rp)-cAMPS Functions as an Antagonist or an Agonist in the Activation of cAMP-dependent Protein Kinase I. Biochemistry 30:8710-8716 (1991

Knighton, D.R., Xuong, Ng. H., Taylor, S.S., and Sowadski, J.M.  Crystallization Studies of cAMP-dependent Protein Kinase:  Cocrystals of the Catalytic Subunit with a Twenty Amino Acid Peptide Inhibitor and MgATP Diffract to 3.0Å Resolution. J. Mol. Biol. 220:217-220 (1991).

Knighton, D.R., Zheng, J., Ten Eyck, L.F., Xuong, Ng. H., Taylor, S.S., and Sowadski, J.M.  Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase. Science 253:414-420 (1991).

Knighton, D.R., Zheng, J., Ten Eyck, L.F., Ashford, V.A., Xuong, Ng. H., Taylor, S.S., and Sowadski, J.M.  Crystal Structure of the Catalytic Subunit of cAMP-dependent Protein Kinase. Science 253:407-414 (1991).

Zoller, M.J., Yonemoto, W., Taylor, S.S., and Johnson, J.E. Mammalian cAMP-dependent Protein Kinase Functionally Replaces its Homolog in Yeast. Gene 99:171-179 (1991).

León, D.A., Dostmann, W.R.G., and Taylor, S.S.  Unfolding of the Regulatory Subunit of cAMP-dependent Protein Kinase I. Biochemistry 30:3035-3040 (1991).

Adams, S.R., Harootunian, A.T., Ji, Y., Taylor, S.S., and Tsien, R.Y.  Fluorescence Ratio Imaging of Cyclic AMP in Single Cells. Nature 349:694-697 (1991).

Ji, Y. and Taylor, S.S.   Mutations in the Autoinhibitor Site of the Regulatory Subunit of cAMP-dependent Protein Kinase I:  Replacement of Ala 97 and Ser 99 Interfere with Reassociation with the Catalytic Subunit. J. Biol. Chem. 266:3491-3497 (1991).

Neitzel, J.J., Dostmann, W.R.G., and Taylor, S.S.  The Role of MgATP in the Activation and Reassociation of cAMP-dependent Protein Kinase I:  Consequences of Replacing the Essential Arginine in cAMP-binding Site A. Biochemistry 30:733-739 (1991).

1990

Meinkoth, J.L., Ji, Y., Taylor, S.S., and Feramisco, J.R.  Dynamics of the Distribution of Cyclic AMP-dependent Protein Kinase in Living Cells. Proc. Nat. Acad. Sci. USA 87:9595-9599 (1990).

Ringheim, G.E. and Taylor, S.S. Effects of cAMP-binding Site Mutations on Intra-Domain Cross-Communication in the Regulatory Subunit of cAMP-dependent Protein Kinase I.  J. Biol. Chem. 265:19472-19478 (1990).

Øgreid, D. and Taylor, S.S.  Expression and Characterization of a Truncated Form of Regulatory Subunit of cAMP-dependent Protein Kinase I Lacking Binding Domain A.  Adv. Second Messenger Phosphoprotein Res. 24: 196-201 (1990).

Duronio, R.J., Jackson-Machelski, E., Heuckeroth, R.O., Olins, P.O., Devine, C.S., Yonemoto, W., Slice, L.W., Taylor, S.S., and Gordon, J.I. Protein N-Myristoylation in Escherichia coli:  Reconstitution of a Eukaryotic Protein Modification in Bacteria. Proc. Nat. Acad. Sci. USA 87:1506-1510 (1990).

Taylor, S.S., Buechler, J.A., and Yonemoto, W.  cAMP-dependent Protein Kinase:  Framework for a Diverse Family of Regulatory Enzymes. Annu. Rev. Biochem. 59:971-1005 (1990).

Dostmann, W.R.G., Taylor, S.S., Genieser, H-G., Jastorff, B., Døskeland, S.O., and Øgreid, D.  Probing the Cyclic Nucleotide Binding Sites of cAMP-dependent Protein Kinases I and II with Analogs of Adenosine 3’,5’-Cyclic Phosphorothioates. J. Biol. Chem. 265:10484-10491 (1990).

Ringheim, G.E. and Taylor, S.S.  Dissecting the Domain Structure of the Regulatory Subunit of cAMP-dependent Protein Kinase I and Elucidating the Role of MgATP. J. Biol. Chem. 265:4800-4808 (1990).

Buechler, J.A. and Taylor, S.S.  Differential Labeling of the Catalytic Subunit of cAMP-dependent Protein Kinase with a Water-Soluble Carbodiimide:  Identification of Carboxyl Groups Protected by MgATP and Inhibitor Peptides. Biochemistry 29:1937-1943 (1990).

1989

Taylor, S.S., Buechler, J.A., and Knighton, D.R. cAMP-dependent Protein Kinase:  Mechanism for ATP:  Protein Phosphotransfer. CRC Critical Reviews, 1-41 (1989).

Slice, L.W. and Taylor, S.S.  Expression of the Catalytic Subunit of cAMP-dependent Protein Kinase in Escherichia coliJ. Biol. Chem. 264:20940-20946 (1989).

Taylor, S.S.  cAMP-dependent Protein Kinase.  Model for an Enzyme Family. J. Biol. Chem. 264:8443-8446 (1989).

First, E.A. and Taylor, S.S.  Selective Modification of the Catalytic Subunit of cAMP-dependent Protein Kinase with Sulfhydryl-Specific Fluorescent Probes. Biochemistry 28:3598-3505 (1989).

First, E.A., Johnson, D.A., and Taylor, S.S.  Fluorescence Energy Transfer between Cys 199 and Cys 343:  Evidence for MgATP-Dependent Conformational Change in the Catalytic Subunit in cAMP-dependent Protein Kinase. Biochemistry 28:3606-3013 (1989).

Durgerian, S. and Taylor, S.S.  The Consequences of Introducing an Autophosphorylation Site into the Type I Regulatory Subunit of cAMP-dependent Protein Kinase. J. Biol. Chem. 264:9807-9813 (1989).

Taylor, S.S., Buechler, J.A., Slice, L.W., Knighton, D.R., Durgerian, S., Ringheim, G.E., Neitzel, J.J., Yonemoto, W.M., Sowadski, J.M., and Dostmann, W.  cAMP-dependent Protein Kinase:  A Framework for a Diverse Family of Enzymes. Cold Spring Harbor Symposia Quantitative Biology 53:121-130 (1989).

Buechler, J.A., Vedvick, T.A., and Taylor, S.S.  Differential Labeling of the Catalytic Subunit of cAMP-dependent Protein Kinase with Acetic Anhydride:  Substrate-Induced Conformational Changes. Biochemistry 28:3018-3024 (1989).

Buechler, J.A. and Taylor, S.S.  Dicyclohexylcarbodiimide Cross-Links Two Conserved Residues, Asp 184 and Lys 72, at the Active Site of the Catalytic Subunit of cAMP-dependent Protein Kinase. Biochemistry 28:2065-2070 (1989).

1988

Ringheim, G.E., Saraswat, L.D., Bubis, J., and Taylor, S.S.  Deletion of cAMP-binding Site ß in the Regulatory Subunit of cAMP-dependent Protein Kinase Alters the Photoaffinity Labeling of Site A.  J. Biol. Chem. 263:18247-18252 (1988).

Saraswat, L.D., Ringheim, G.E., Bubis, J., and Taylor, S.S.  Deletion Mutants as Probes for Localizing Regions of Subunit Interaction in cAMP-dependent Protein Kinase. J. Biol. Chem. 263: 18241-18246 (1988).

Taylor, S.S., Bubis, J., Toner-Webb, J., Saraswat, L.D., First, E.A., Buechler, J.A., Knighton, D.R., and Sowadski, J.M. cAMP-dependent Protein Kinase:  Prototype for a Family of Enzymes. FASEB  2:2677-2685 (1988).

Buechler, J.A. and Taylor, S. S.  Identification of Aspartate-184 as an Essential Residue in the Catalytic Subunit of cAMP-dependent Protein Kinase. Biochemistry 27:7356-7361 (1988).

Bubis, J., Neitzel, J.J., Saraswat, L.D., and Taylor, S.S.  A Point Mutation Abolishes Binding of cAMP to Site A in the Regulatory Subunit of cAMP-dependent Protein Kinase. J. Biol. Chem. 263:9668-9673 (1988).

Gibney, G., MacPhee-Quigley, K., Thompson, B., Vedvick, T., Low, M.G., Taylor, S.S., and Taylor, P.     Divergence in Primary Structure Between the Molecular Forms of Acetylcholinesterase. J. Biol. Chem. 263:1140-1145 (1988).

First, E.A., Bubis, J., and Taylor, S.S.  Subunit Interaction Sites Between the Regulatory and Catalytic Subunits of cAMP-dependent Protein Kinases:  Identification of a Specific Interchain Disulfide Bond. J. Biol. Chem. 263:5177-5182 (1988).

First, E.A. and Taylor, S.S.  Subunit Interaction Sites between the Regulatory and Catalytic Subunits of cAMP-dependent Protein Kinase:  Heterobifunctional Cross-Linking Reagents Lead to Photodependent and Photoindependent Cross-Linking. J. Biol. Chem. 263:5170-5175 (1988).

Bubis, J., Saraswat, L.D., and Taylor, S.S.  Tyrosine 371 Contributes to the Positive Cooperativity Between the Two cAMP Binding Sites in the Regulatory Subunit of cAMP-dependent Protein Kinase I. Biochemistry 27:1570-1576 (1988).

Bubis, J. and Taylor, S.S. Limited Proteolysis Alters the Photoaffinity Labeling of Adenosine 3’,5’-Monophosphate Dependent Protein Kinase II with 8-Azidoadenosine 3’,5’-Monophosphate. Biochemistry 26:5997-6004 (1988).

Saraswat, L.D., Filutowics, M., and Taylor, S.S.  Expression and Mutagenesis of the  Regulatory Subunit of cAMP-dependent Protein Kinase in Escherichia ColiMethods In Enzymology 159:325-336 (1988).

1987

Expression and Mutagenesis of the Bovine Type I Regulatory Subunit of cAMP-dependent Protein Kinase.  Bubis, J., Saraswat, L.D., Reynolds, P., and Taylor, S.S.  Protein Structure and Design 2, UCLA Symposia, New Series, Alan R. Liss, Inc., NY, 401-414 (1987).

Antiparallel Alignment of the Two Protomers of the Regulatory Subunits of the Regulatory Subunit Dimer of cAMP-dependent Protein Kinase I.  Bubis, J., Vedvick T.S., and Taylor. S.S.   J. Biol. Chem. 262:14961-14966 (1987).

Inhibition of the Catalytic Subunit of cAMP-dependent Protein Kinase by  Dicyclohexylcarbodiimide.  Toner-Webb, J. and Taylor, S.S. Biochemistry 26:7371-7378 (1987).

The Structure of Acetylcholinesterase:  Relationship to its Function and Cellular Disposition.  Taylor, P., Schumacher, M., MacPhee-Quigley, K., Friedmann, T., and Taylor, S.S.  Trends in Neurosciences 10:93-95 (1987).

Protein Kinases:  a Diverse Family of Related Proteins.  Taylor, S.S.  BioEssays 7:24-29 (1987).

Correlation of Photolabeling with Occupancy of cAMP-binding Sites in the Regulatory Subunit of cAMP-dependent Protein Kinase I.  Bubis, J. and Taylor, S.S.  Biochemistry 26:3478-3486 (1987).

Predicted Structures of the cAMP Binding Domains of the Type I and II Regulatory Subunits of cAMP-dependent Protein Kinase.  Weber, I.T., Steitz, T.A., Bubis, J., and Taylor, S.S.  Biochemistry 26:343-351 (1987).

1986

Schumacher, M., Camp, S., Maulet, Y., Newton, M., Macphee-Quigley, K., Taylor, S.S., Friedmann, T., and Taylor, P.  Primary Structure of Acetylcholinesterase:  Implications for Regulation and Function. Federation Proceedings 45:2976-2981 (1986).

Taylor, S.S., Bubis, J., Sowadski, J.M., Toner, J.A., and Saraswat, L.D.  Relation Between Structure and Function in cAMP-dependent Protein Kinases. Enzyme Dynamics and Regulation, Springer-Verlag, New York, 327-341 (1986).

MacPhee-Quigley, K., Vedvick, T.S., Taylor, P., and Taylor, S.S.  Profile of the Disulfide Bonds in Acetylcholinesterase. J. Biol. Chem. 261:13565-13570 (1986).

Taylor, S.S., Saraswat, L.D., Toner, J.A., and Bubis, J.  The Relationship between Structure and Function in cAMP-dependent Protein Kinases Annals N. Y. Acad. Sci. 478:191-202 (1986).

Macphee-Quigley, K., Vedvick, T.S., Taylor, P., and Taylor, S.S.  Active Site and Other Sequence Data from Torpedo californica acetylcholinesterase. Modern Methods in Protein Chemistry (Ed., J. L’Italien), Plenum Press, New York (1986).

Saraswat, L.D., Filutowics, M., and Taylor, S.S.  Expression of the Type I Regulatory Subunit of cAMP-dependent Protein Kinase in Escherichia coliJ. Biol. Chem. 261:11091-11096 (1986).

Schumaker, M., Camp, S., Maulet, Y., Newton, M., MacPhee-Quigley, K., Taylor, S.S., Friedmann, T., and Taylor, P.  Primary Structure of Torpedo californica Acetylcholinesterase Deduced from its cDNA Sequence. Nature 319:407-409 (1986).

1985

Jurgensen, S.R., Chock, P.B., Taylor, S.S., Vandenheede, J.R., and Merlevede, W.  Inhibition of the Mg(II)•ATP-dependent Phosphoprotein Phosphatase by the Regulatory Subunit of cAMP-dependent Protein Kinase. Proc. Nat. Acad. Sci. USA 82:7565-7569 (1985).

Mumby, M.C., Weldon, S.L., Scott, C.W., and Taylor, S.S. Monoclonal Antibodies as Probes of Structure, Function and Isoenzyme Forms of the Type II Regulatory Subunit of Cylcic AMP-dependent Protein Kinase. Pharmac. Ther. 28:367-387 (1985).

MacPhee-Quigley, K., Taylor, P., and Taylor, S.S.  Primary Structures of the Catalytic Subunits from Two Molecular Forms of Acetylcholinesterase:  A Comparison of NH2-terminal and Active Center Sequences. J. Biol. Chem. 260:12185-12189 (1985).

Dothie, J.M., Giglio, J.R., Moore, C.B., Taylor, S.S., and Hartley, B.S.  Ribitol Dehydrogenase from Klebsiella aerogenes:  Sequence and Properties of Wild Type and Mutant Strains. Biochem. J. 230:569-578 (1985).

Weldon, S.L., Mumby, M.C., and Taylor, S.S.  The Regulatory Subunit of Neural cAMP-dependent Protein Kinase II Represents a Unique Gene Product. J. Biol. Chem. 260:6440-6448 (1985).

Sowadski, J.M., Xuong, Ng. H., Anderson, D., and Taylor, S.S.  Crystallization Studies of cAMP-dependent Protein Kinase:  Crystals of Catalytic Subunit Diffract to 3.5 Å Resolution. J. Mol. Biol. 182:617-620 (1985).

Bubis, J. and Taylor, S.S.  Covalent Modification of Both cAMP Binding Sites in cAMP-dependent Protein Kinase I by 8-Azidoadenosine 3’,5’-Monophosphate. Biochemistry 24:2163-2170 (1985).

Weldon, S.L. and Taylor, S.S.  Monoclonal Antibodies as Probes for Functional Domains in cAMP-dependent Protein Kinase II. J. Biol. Chem. 260:4203-4209 (1985).

1984

Taylor, P., Camp, S., Lee, S., Amitai, G., Taylor, S.S., and Doctor, B.P.  Molecular Aspects of the Biosynthesis and Disposition of Multiple Forms of Acetylcholinesterase. Cholinesterases:  Fundamental and Applied Aspects (Eds., M. Brzin, E.A. Barnard, and D. Sket), 145-154 (1984).

Kamps, M.P., Taylor, S.S., and Sefton, B.M.  Direct Evidence that Oncogenic Tyrosine Kinases and Cyclic AMP-dependent Protein Kinase have Homologous ATP-binding Sites. Nature 310:589-592 (1984).

Cooper, J.A., Esch, F.S., Taylor, S.S., and Hunter, T. Phosphorylation Sites in Enolase and Lactate Dehydrogenase Utilized by Tyrosine Protein Kinases in Vivo and in VitroJ. Biol. Chem. 259: 7835-7841 (1984).

First, E.A. and Taylor, S.S. Induced Interchain Disulfide Bonding in cAMP-dependent Protein Kinase II. J. Biol. Chem. 259:4011-4014 (1984).

1983

Siebenaller, J.F., Orr, T.L., Oliver, B.B., and Taylor, S.S.  Comparison of the D-Lactate Stereospecific Dehydrogenase of Limulus polyphemus with Active-Site Regions of l-Lactate Dehydrogenases. Biochimica of Biophysica Acta  749:153-162 (1983).

Doctor, B.P., Camp,  S., Gentry,  M.K., Taylor, S.S., and Taylor, P. Antigenic and Structural Differences in the Catalytic Subunits of the Molecular Forms of Acetylcholinesterase. Proc. Nat. Acad. Sci. USA 80:5767-5771 (1983).

Nelson, N.C. and Taylor, S.S. Selective Protection of Sulfydryl Groups in cAMP-dependent Protein Kinase II. J. Biol. Chem. 258:10981-10987 (1983).

Weldon, S.L., Mumby, M.C., Beavo, J.A., and Taylor, S.S.  Monoclonal Antibodies as Structural Probes of Surface Residues in the Regulatory Subunit of cAMP-dependent Protein Kinase II from Porcine Heart. J. Biol. Chem. 258:1129-1135 (1983).

Bramson,  N.H., Thomas,  N., Matsueda,  R., Nelson, N.C., Taylor, S.S., and Kaiser, E.T.  Modification of the Catalytic Subunit of Bovine Heart cAMP-dependent Protein Kinase with Affinity Labels Related to Peptide Substrates. J. Biol. Chem. 257:10575-10581 (1983).

Taylor, S.S., Kerlavage, A.R., and Zoller, M.J.  Affinity Labeling of cAMP-dependent Protein Kinases. Methods In  Enzymology (Eds., J.D. Corbin and J.G. Hardman) 99:140-153 (1983).

1982

Taylor, S.S., Kerlavage, A., Nelson, N., Weldon, S., and Zoller, M.  Use of High Performance Liquid Chromatography in Characterizing Nucleotide Binding Sites and Antigenic Determinants in cAMP-dependent Protein Kinase. Methods Protein Sequence Analysis (Ed., M. Elzinga), 471-478 (1982).

Paulson, J.R. and Taylor, S.S. Phosphorylation of Histones 1 and 3 and Nonhistone High Mobility Group 14 by an Endogenous Kinase in HeLa Metaphase Chromosomes. J. Biol. Chem. 257: 6064-6052 (1982).

Taylor, S.S.  The in Vitro Phosphorylation of Chromatin by the Catalytic Subunit of cAMP-dependent Protein Kinase. J. Biol. Chem. 257:6056-6063 (1982).

Zick, S.K. and Taylor, S.S.  Interchain Disulfide Bonding in the Regulatory Subunit of cAMP-dependent Protein Kinase I. J. Biol. Chem. 257:2287-2293 (1982).

Kerlavage, A.R. and Taylor, S.S.  Site-specific Cyclic Nucleotide Binding and Dissociation of the Holoenzyme of cAMP-dependent Protein Kinase. J. Biol. Chem. 257:1749-1754 (1982).

1981

Zoller, M.J., Nelson, N.C., and Taylor, S.S.  Affinity Labeling of cAMP-dependent Protein Kinase with p-Fluorosulfonylbenzoyl Adenosine:  Covalent Modification of Lysine 71. J. Biol. Chem. 256:10837-10842 (1981).

Nelson, N.C. and Taylor, S.S.  Differential Labeling and Identification of the Cysteine-containing Tryptic Peptides of Catalytic Subunit from Porcine Heart cAMP-dependent Protein Kinase. J. Biol. Chem. 256:3743-3750 (1981).

Taylor, S.S., Kerlavage, A.R., Zoller,  M.J., Nelson, N.C., and Potter, R.L.  Nucleotide-binding Sites and Structural Domains of cAMP-dependent Protein Kinases. Cold Spring Harbor Conferences on Cell Proliferation 8:3-18 (1981).

1980

Potter, R.L. and Taylor, S.S. The Structural Domains of cAMP-dependent Protein Kinase I:  Characterization of Two Sites of Proteolytic Cleavage and Homologies to cAMP-dependent Protein Kinase II. J. Biol. Chem. 255:9706- 9712 (1980).

Kerlavage, A.R. and Taylor, S.S.Covalent Modification of an Adenine 3’:5’-Monophosphate Binding Site of the Regulatory Subunit of cAMP-dependent Protein Kinase II with 8-Azidoadenosine 3’:5’-Monophosphate:  Identification of a Single Modified Tyrosine Residue. J. Biol. Chem. 255: 8483-8488 (1980).

1979

Potter, R.L. and Taylor, S.S.  Correlation of the cAMP-binding Domain with a Site of Autophosphorylation on the Regulatory Subunit of cAMP-dependent Protein Kinase II from Porcine Skeletal Muscle. J. Biol. Chem. 254:9000-9005 (1979).

Zoller, M.J. and Taylor, S.S. Affinity Labeling of the Nucleotide Binding Site of the Catalytic Subunit of cAMP-dependent Protein Kinase Using p-Fluorosulfonyl-[14C]benzoyl 5’-Adenosine:  Identification of a Modified Lysine Residue. J. Biol. Chem. 254:8363-8368 (1979).

Potter, R.L. and Taylor, S.S.  Relationships between Structural Domains and Function in the Regulatory Subunit of cAMP-dependent Protein Kinases I and II from Porcine Skeletal Muscle. J. Biol. Chem. 254:2413-2418 (1979).

Zoller, M.J., Kerlavage, A.R., and Taylor, S.S.  Structural Comparisons of cAMP-dependent Protein Kinases I and II from Porcine Skeletal Muscle. J. Biol. Chem. 254:2408-2412 (1979).

1978

Potter, R.L., Stafford, P.H., and Taylor, S.S.  ARegulatory Subunit of Cyclic AMP-dependent Protein Kinase I from Porcine Skeletal Muscle:  Purification and Proteolysis.  rchives of Biochemistry and Biophysics 190:174-180 (1978).

Taylor, S.S. and Dixon, J.E.  Affinity Chromatography of Lactate Dehydrogenase:  A Biochemistry Experiment. Journal of Chemical Education 55:675-677 (1978).

Taylor, S.S. and Stafford, P.H.  Characterization of Adenosine 3’:5’-Monophosphate-dependent Protein Kinase and Its Dissociated Subunits from Porcine Skeletal Muscle. J. Biol. Chem. 253:2284-2287 (1978).

1977

Eventoff, W., Rossman, M.G., Taylor, S.S., Torff, H-J., Meyer, H., Keill, W., and Kiltz, H.H.  Structural Adaptations of Lactate Dehydrogenase Isoenzymes. Proc. Nat. Acad. Sci. USA 74: 2677-2681 (1977).

Taylor, S.S.  Amino Acid Sequence of Dogfish Muscle Lactate Dehydrogenase. J. Biol. Chem. 252:1799-1806 (1977).

1976

Taylor, S.S., Lee, C-Y.L., Swain, L., and Stafford, P.H.  Cyclic-AMP-Dependent Protein Kinase:  Purification of the Holoenzyme by Affinity Chromatography. Analytical Biochemistry 76:45-52 (1976).

Taylor, S.S. and Oxley, S.S.  Homologies in the Active Site Regions of Lactate Dehydrogenases. Archives of Biochemistry and Biophysics 175:373-383 (1976).

1975
Taylor, S.S., Allison, W.S., and Kaplan, N.O.  The Amino Acid Sequence of the Tryptic Peptides Isolated from Dogfish M4 Lactate Dehydrogenase. J. Biol. Chem. 250:8740-8747 (1975).
1974

Kaplan, N.O., Everse, J., Dixon, J.E., Stolzenback, F.E., Lee, C-Y., Lee, C-L.T., Taylor, S.S.,  and Mosback, K. Purification and Separation of Pyridine Nucleotide-Linked Dehydrogenases by Affinity Chromatography Techniques. Proc. Nat. Acad. Sci. USA 71:3450-3454 (1974).

Taylor, S.S., Rigby, P.W.J., and Hartley, B.S.  Ribitol Dehydrogenase from Klebsiella aerogenes:  Purification and Subunit Structure. Biochem. J. 141:693-700 (1974).

1973

Adams, M.J., Buehner, K., Chandrasekhar, K., Ford, G.C., Hackert, M.L., Liljas, A., Rossman, M.G., Smiley, I.E., Allison, W.S., Everse, J., Kaplan, N.O., and Taylor, S.S.  Structure-Function Relationships in Lactate Dehydrogenase. Proc. Nat. Acad. Sci. USA 70:1968-1972 (1973).

Taylor, S.S., Oxley, S.S., Allison, W.S., and Kaplan, N.O.  Aminoacid Sequence of Dogfish M4 Lactate Dehydrogenase. Proc. Nat. Acad. Sci. USA 70:1790-1794 (1973).

1972
Hartley, B.S., Burleigh, B.D., Midwinter, G.G., Moore, C.H., Morris, H.R., Rigby, P.W.J., Smith, M.J., and Taylor, S.S.Where Do New Enzymes Come From?   FEBS Symposium 29:151-176, North-Holland, London (1972).
1969
Taylor, S.S. and Heath, E.C.  The Incorporation of  b-Hydroxy Fatty Acids into a Phospholipid of Escherichia coli B. J. Biol. Chem. 244:6605-6616 (1969).